Τίτλος:
Transcranial alternating current stimulation reduces symptoms in intractable idiopathic cervical dystonia: A case study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Idiopathic cervical dystonia (ICD) is a movement disorder often resulting in profound disability and pain. Treatment options include oral medications or other invasive procedures, whereas intractable ICD has been shown to respond to invasive (deep) brain stimulation. In the present blinded, placebo-controlled case study, transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS) has been applied to a 54-year old patient with intractable ICD. Results showed that 15. Hz tACS had both immediate and cumulative effects in dystonic symptom reduction, with a 54% reduction in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score, and a 75% in the TWSTRS Pain Scale. These effects were persistent at 30-days follow-up. This is the first report to demonstrate a significant and lasting therapeutic effect of non-invasive electrical brain stimulation in dystonia. © 2012 Elsevier Ireland Ltd.
Συγγραφείς:
Angelakis, E.
Liouta, E.
Andreadis, N.
Leonardos, A.
Ktonas, P.
Stavrinou, L.C.
Miranda, P.C.
Mekonnen, A.
Sakas, D.E.
Περιοδικό:
Neuroscience Letters
Λέξεις-κλειδιά:
baclofen; botulinum toxin; clonazepam; etiracetam; gabapentin; placebo; pregabalin; trihexyphenidyl; venlafaxine, adult; article; case report; cervical dystonia; controlled study; female; follow up; human; idiopathic disease; intractable idiopathic cervical dystonia; nerve stimulation; pain assessment; priority journal; rating scale; single blind procedure; transcranial alternating current stimulation; transcranial direct current stimulation, Deep Brain Stimulation; Female; Humans; Middle Aged; Pain, Intractable; Torticollis
DOI:
10.1016/j.neulet.2012.11.007
