Τίτλος:
Fluorescein and indocyanine-green angiography in ocular syphilis: An exploratory study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background Fluorescein (FA) and indocyanine-green angiography (ICGA) may offer valuable information concerning disease severity and prognosis in ocular syphilis. The aim of the present study is to describe angiographic patterns encountered in the context of ocular syphilis, and to explore the associations between specific angiographic manifestations and severity of disease presentation, as well as disease evolution after treatment. Methods We performed a retrospective institutional study with the inclusion of 23 patients with ocular syphilis presenting to the uveitis clinic of the Jules-Gonin Eye Hospital in a 10-year period. FA and ICGAwere performed following a standard protocol for posterior uveitis. Patterns of fluorescence were noted, and statistical associations between each angiographic pattern and any demographic, clinical, or laboratory parameter at baseline and after treatment were sought. Results The presence of any dark dots in ICGA was significantly associated with anterior uveitis (p=0.031). The presence of hot spots in ICGA was significantly associated with longer duration of symptoms prior to initial visit (p= 0.032) and with male gender (p=0.012). Weak nonsignificant trends were found associating vascular staining in FAwith anterior uveitis (p=0.066), vitritis (p=0.069), and younger age (p=0.061), as well as disc hyperfluorescence in FA with seropositivity for HIV (p=0.089) and macular edema in FA with longer disease duration (p=0.061). The presence of any dark dots in ICGA exhibited a weak trend of association with anterior uveitis and/or vitritis (p=0.079). Conclusions Out of the several associations identified implicating specific angiographic features, we underline the possible role of the presence of dark dots in ICGA for identifying active inflammation, and the role of hot spots in ICGA as markers of long-standing disease. Vascular staining in FA appears to be more common in patients with severe ocular inflammation with presence of anterior uveitis and/or vitritis. © 2011 Springer-Verlag.
Συγγραφείς:
Balaskas, K.
Sergentanis, T.N.
Giulieri, S.
Guex-Crosier, Y.
Περιοδικό:
Graefe's Archive for Clinical and Experimental Ophthalmology
Λέξεις-κλειδιά:
ceftriaxone; penicillin G, age distribution; article; clinical article; controlled study; disease association; disease duration; disease severity; eye infection; female; fluorescence angiography; fluorescence imaging; human; Human immunodeficiency virus infection; image analysis; indocyanine green angiography; iridocyclitis; male; ocular blood vessel; ocular syphilis; priority journal; retina macula edema; retrospective study; sex difference; syphilis; treatment response; vitritis, Adult; Ceftriaxone; Coloring Agents; Eye Infections, Bacterial; Female; Fluorescein Angiography; Humans; Indocyanine Green; Injections, Intravenous; Male; Middle Aged; Penicillins; Retrospective Studies; Syphilis; Syphilis Serodiagnosis; Uveitis
DOI:
10.1007/s00417-011-1893-4
