Τίτλος:
Adult consequences of post-weaning high fat feeding on the limbic-HPA axis of female rats
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The peripubertal period is critical for the final maturation of circuits controlling energy homeostasis and stress response. However, the consequence of juvenile fat consumption on adult physiology is not clear. This study analyzed the adult consequences of post-weaning fat feeding on limbic-hypothalamic- pituitary-adrenal (HPA) axis components and on metabolic regulators of female rats. Wistar rats were fed either a high fat (HF) diet or the normal chow from weaning to puberty or to 3 months of age. Additional groups crossed their diets at puberty onset. Plasma leptin, insulin, and corticosterone levels were determined by radioimmunoassay and their brain receptors by western blot analysis. Adult HF-fed animals though not overweight, had higher corticosterone and reduced glucocorticoid receptor levels in the hypothalamus and hippocampus, compared to the controls. The alterations in HPA axis emerged already at puberty onset. Leptin receptor levels in the hypothalamus were reduced only by continuous fat feeding from weaning to adulthood. The prepubertal period appeared more vulnerable to diet-induced alterations in adulthood than the post-pubertal one. Switching from fat diet to normal chow at puberty onset restored most of the diet-induced alterations in the HPA axis. The corticosteroid circuit rather than the leptin or insulin system appears as the principal target for the peripubertal fat diet-induced effects in adult female rats. © Springer Science+Business Media, LLC 2009.
Συγγραφείς:
Boukouvalas, G.
Gerozissis, K.
Kitraki, E.
Περιοδικό:
Cellular and Molecular Neurobiology
Λέξεις-κλειδιά:
corticosterone; glucocorticoid receptor; insulin; leptin receptor, animal experiment; article; controlled study; corticosterone blood level; feeding behavior; female; hippocampus; hypothalamus; hypothalamus hypophysis adrenal system; insulin blood level; limbic system; lipid diet; metabolic regulation; nonhuman; priority journal; radioimmunoassay; rat; weaning; Western blotting, Animals; Blood Glucose; Body Weight; Corticosterone; Dietary Fats; Eating; Female; Hypothalamo-Hypophyseal System; Insulin; Leptin; Limbic System; Pituitary-Adrenal System; Puberty; Random Allocation; Rats; Rats, Wistar; Receptors, Glucocorticoid; Receptors, Leptin; Weaning, Animalia; Rattus; Rattus norvegicus
DOI:
10.1007/s10571-009-9476-1
