Τίτλος:
Signs of striatal dopamine transporter density increase in association with improvement of tardive dyskinesia in a patient with schizophrenia, as demonstrated by a DAT scan
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The imaging of the dopamine transporter could demonstrate the implication of dopaminergic pathway in the appearance of tardive dyskinesia. We report a case with psychotic and tardive dyskinesia symptoms. A DAT scan showed decreased dopamine transporter uptake in the area of brain's basal gaglia. A trial with quetiapine improved both psychotic and TD symptoms while a second DAT scan showed improvement status. We conclude that increased dopamine transporter uptake seemed to associate with the improvement of TD. © 2009 Elsevier B.V. All rights reserved.
Συγγραφείς:
Rizos, E.N.
Chatziioannou, S.
Douzenis, A.
Siafakas, N.
Katsantoni, E.
Nikolaidou, P.
Papathanasiou, M.
Lykouras, L.
Περιοδικό:
European Neuropsychopharmacology
Λέξεις-κλειδιά:
dopamine transporter; olanzapine; quetiapine; risperidone, aged; article; auditory hallucination; basal ganglion; brain atrophy; case report; clinical feature; delusion; drug dose increase; drug dose titration; drug withdrawal; female; human; nuclear magnetic resonance imaging; priority journal; schizophrenia; single photon emission computer tomography; tardive dyskinesia; tremor, Aged; Antipsychotic Agents; Corpus Striatum; Dibenzothiazepines; Dopamine Plasma Membrane Transport Proteins; Dyskinesia, Drug-Induced; Female; Humans; Schizophrenia; Tomography, Emission-Computed, Single-Photon
DOI:
10.1016/j.euroneuro.2009.08.002
