Περίληψη:
Background: Clinical presentations of coronavirus disease 2019 (COVID-19) among children with asthma have rarely been investigated. This study aimed to assess clinical manifestations and outcome of COVID-19 among children with asthma, and whether the use of asthma medications was associated with outcomes of interest. Methods: The Global Asthma Network (GAN) conducted a global survey among GAN centers. Data collection was between November 2020 and April 2021. Results: Fourteen GAN centers from 10 countries provided data on 169 children with asthma infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 was asymptomatic in 58 (34.3%), mild in 93 (55.0%), moderate in 14 (8.3%), and severe/critical in 4 (2.4%). Thirty-eight (22.5%) patients had exacerbation of asthma and 21 (12.4%) were hospitalized for a median of 7 days (interquartile range 3–16). Those who had moderate or more severe COVID-19 were significantly more likely to have exacerbation of asthma as compared to those who were asymptomatic or had mild COVID-19 (adjusted odds ratio (adjOR) 3.97, 95% CI 1.23–12.84). Those who used inhaled bronchodilators were significantly more likely to have a change of asthma medications (adjOR 2.39, 95% CI 1.02–5.63) compared to those who did not. Children who used inhaled corticosteroids (ICS) did not differ from those who did not use ICS with regard to being symptomatic, severity of COVID-19, asthma exacerbation, and hospitalization. Conclusions: Over dependence on inhaled bronchodilator may be inappropriate. Use of ICS may be safe and should be continued in children with asthma during the pandemic of COVID-19. © 2021 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Συγγραφείς:
Chiang, C.-Y.
Ellwood, P.
Ellwood, E.
García-Marcos, L.
Masekela, R.
Asher, I.
Badellino, H.
Sanz, A.B.
Douros, K.
El Sony, A.
Diaz, C.G.
Rodríguez, M.S.A.
Moreno-Salvador, A.
Pérez-Martini, L.F.
Filho, N.
Shpakou, A.
Sulaimanov, S.
Tavakol, M.
Valverde-Molina, J.
Yousef, A.A.
Pearce, N.
The GAN COVID Study Group
Λέξεις-κλειδιά:
corticosteroid, asthma; child; human; pandemic, Adrenal Cortex Hormones; Asthma; Child; COVID-19; Humans; Pandemics; SARS-CoV-2
