Περίληψη:
COVID-19 is a global pandemic associated with increased morbidity and mortality. Convalescent plasma (CP) infusion is a strategy of potential therapeutic benefit. We conducted a multicenter phase II study to evaluate the efficacy and safety of CP in patients with COVID-19, grade 4 or higher. To evaluate the efficacy of CP, a matched propensity score analysis was used comparing the intervention (n = 59) to a control group (n = 59). Sixty patients received CP within a median time of 7 days from symptom onset. During a median follow-up of 28.5 days, 56/60 patients fully recovered and 1 patient remained in the ICU. The death rate in the CP group was 3.4% vs. 13.6% in the control group. By multivariate analysis, CP recipients demonstrated a significantly reduced risk of death [HR: 0.04 (95% CI: 0.004–0.36), p: 0.005], significantly better overall survival by Kaplan–Meir analysis (p < 0.001), and increased probability of extubation [OR: 30.3 (95% CI: 2.64–348.9), p: 0.006]. Higher levels of antibodies in the CP were independently associated with significantly reduced risk of death. CP infusion was safe with only one grade 3 adverse event (AE), which easily resolved. CP used early may be a safe and effective treatment for patients with severe COVID-19 (trial number NCT04408209). © 2021 by the au-thors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Pappa, V.
Bouchla, A.
Terpos, E.
Thomopoulos, T.P.
Rosati, M.
Stellas, D.
Antoniadou, A.
Mentis, A.
Papageorgiou, S.G.
Politou, M.
Kotanidou, A.
Kalomenidis, I.
Poulakou, G.
Jahaj, E.
Korompoki, E.
Grigoropoulou, S.
Hu, X.
Bear, J.
Karaliota, S.
Burns, R.
Pagoni, M.
Trontzas, I.
Grouzi, E.
Labropoulou, S.
Stamoulis, K.
Bamias, A.
Tsiodras, S.
Felber, B.K.
Pavlakis, G.N.
Dimopoulos, M.-A.
