Τίτλος:
A novel ratio of CD8+:B-cells as a prognostic marker of coronavirus disease 2019 patient progression and outcome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Infection with SARS-COV-2 may result in severe pneumonia potentially leading to mechanical ventilation and intensive care treatment. The aim of the present study was to analyze the immune responses in critically ill coronavirus 2019 (COVID-19) patients requiring mechanical ventilation and assess their potential use as markers of clinical progression and outcome. Confirmed COVID-19 patients were grouped into those requiring mechanical ventilation (intubated) and non-intubated. Immune phenotyping was performed and cytokine levels were determined. A novel ratio of CD8+:B cells was significantly lower in intubated versus non-intubated (p = 0.015) and intubated non-survivors (NSV) versus survivors (SV) (p = 0.015). The same ratio correlated with outcome, CRP, IL-6 levels and neutrophil count. Receiving operating curve (ROC) analysis for prediction of requirement of mechanical ventilation by the CD8+:B cells ratio revealed an AUC of 0.747 and a p = 0.007. The ratio of CD8+:B cells may serve as a useful prognostic marker for disease severity and outcome. © 2021
Συγγραφείς:
Detsika, M.G.
Ampelakiotou, K.
Grigoriou, E.
Psarra, K.
Jahaj, E.
Roussos, C.
Dimopoulou, I.
Orfanos, S.E.
Tsirogianni, A.
Kotanidou, A.
Εκδότης:
Academic Press Inc.
Λέξεις-κλειδιά:
C reactive protein; interleukin 10; interleukin 1beta; interleukin 6; interleukin 8; biological marker; cytokine, adult; Article; artificial ventilation; CD8+ T lymphocyte B lymphocyte ratio; clinical article; cohort analysis; controlled study; coronavirus disease 2019; critically ill patient; disease severity; female; human; immune response; immunological parameters; immunophenotyping; intubation; male; middle aged; neutrophil count; prediction; prognosis; protein blood level; receiver operating characteristic; sensitivity and specificity; survivor; treatment outcome; aged; B lymphocyte; blood; CD8+ T lymphocyte; critical illness; immunology; lymphocyte count; pathology; prognosis; therapy, Aged; B-Lymphocytes; Biomarkers; CD8-Positive T-Lymphocytes; COVID-19; Critical Illness; Cytokines; Female; Humans; Immunophenotyping; Lymphocyte Count; Male; Middle Aged; Prognosis; Respiration, Artificial; SARS-CoV-2; Treatment Outcome
DOI:
10.1016/j.virol.2021.01.002
