Τίτλος:
Clinical correlates of rhinovirus infection in preschool asthma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Investigation of preschool asthma is important since not all children outgrow their illness during this age. Data are scarce on the role of rhinovirus (RV) infections in this patient group. Objectives: To investigate the role of RV infections in preschool asthma: (i) susceptibility factors, (ii) clinical course, and (iii) medium-term outcome. Methods: A total of 130 asthmatic children aged 4-6 years from the multinational PreDicta cohort were prospectively followed for a 12-month period. Allergy tests and a standard health questionnaire were carried out at study entry. Respiratory virus presence in nasopharyngeal washes was studied at illness visits and at 3 scheduled visits. Results: At study entry, mean age of the children was 5.3 years. Of 571 visits, 54% were positive for any virus and 39% for RV. Patient characteristics were only assessed with RV infection due to low number of other viruses. The use of supplementary vitamin D was inversely associated with RV infection (P <.05). RV infection was associated with more severe course of acute illness in terms of more severe nighttime coughing, more sleep disturbances, and more days with runny nose (all P <.05). RV infection was also associated with more severe disease course during the 12-month follow-up in terms of more nights with awakenings and more days of exercise-related symptoms (both P <.05). Conclusions: Vitamin D supplementation may have an anti-rhinovirus effect. Both short- and medium-term outcomes suggest RV infection to be an important clinical marker of instable preschool asthma. © 2020 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd
Συγγραφείς:
Jartti, T.
Liimatainen, U.
Xepapadaki, P.
Vahlberg, T.
Bachert, C.
Finotto, S.
Kowalski, M.L.
Sobanska, A.
Lukkarinen, H.
Pasioti, M.
Vuorinen, T.
Zhang, N.
Zimmermann, T.
Papadopoulos, N.G.
Περιοδικό:
Allergy: European Journal of Allergy and Clinical Immunology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
beta 2 adrenergic receptor stimulating agent; corticosteroid; leukotriene receptor blocking agent; vitamin D; yoghurt, allergy test; antiviral activity; arousal; Article; asthma; atopic dermatitis; cereal; child; clinical assessment; clinical outcome; cohort analysis; controlled study; coughing; data analysis software; disease course; disease marker; disease severity; exercise; female; follow up; fortified food; human; infection sensitivity; major clinical study; male; mild intermittent asthma; mild persistent asthma; milk; mixed infection; moderate persistent asthma; nasopharyngeal swab; night; nonhuman; outcome assessment; parental smoking; peak expiratory flow; pet animal; preschool child; priority journal; prognosis; questionnaire; respiratory virus; rhinitis; rhinorrhea; Rhinovirus; Rhinovirus infection; risk factor; sensitization; sleep disorder; symptomatology; virus detection; vitamin supplementation; asthma; disease exacerbation; Rhinovirus, Asthma; Child; Child, Preschool; Cohort Studies; Disease Progression; Humans; Rhinovirus
