Τίτλος:
Case of an unusual diagnosis of primary antiphospholipid syndrome with multiple clinical complications
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Antiphospholipid syndrome (APS) is a systemic autoimmune disease defined by the presence of antiphospholipid antibodies in association with thrombotic events and/or obstetric complications. Renal involvement is not infrequent in both primary and secondary APS. Kidney manifestations comprise a wide range of clinical features, including hypertension, major renal vessel thrombosis or microvascular endothelial injury, also described as APS nephropathy. In the absence of a thrombotic event, clinical manifestations of APS are often non-specific. We recently encountered a case of primary APS in a young male with newly diagnosed hypertension and renal impairment. The diagnosis of APS was initially suspected by his kidney biopsy findings, when electron microscopy examination showed the features of chronic microangiopathy, and was later confirmed by a triple positive antiphospholipid antibody profile and multiple organ involvement. © The Author(s) 2020.
Συγγραφείς:
Tsiakas, S.
Skalioti, C.
Kotsi, P.
Boletis, I.
Marinaki, S.
Περιοδικό:
Oxford Medical Case Reports
Εκδότης:
Oxford University Press
Λέξεις-κλειδιά:
acenocoumarol; acetylsalicylic acid; cardiolipin antibody; creatinine; low molecular weight heparin; phospholipid antibody; troponin T, adult; anticoagulant therapy; antihypertensive activity; antiphospholipid syndrome; artery constriction; Article; blurred vision; case report; clinical article; drug substitution; focal glomerulosclerosis; headache; heart catheterization; heart muscle ischemia; hematoma; human; hypertension; immune complex deposition; ischemic glomerular lesion; ischemic mitral valve regurgitation; kidney biopsy; kidney failure; kidney fibrosis; kidney injury; male; nephrotic syndrome; nuclear magnetic resonance imaging; ophthalmoscopy; protein urine level; prothrombin time; retinal vascular disease; ST segment depression; systolic heart murmur; thrombotic thrombocytopenic purpura; transesophageal echocardiography; transthoracic echocardiography; upper abdominal pain; upper respiratory tract infection; white matter lesion
DOI:
10.1093/omcr/omaa117
