Τίτλος:
Antibiotic treatment and antimicrobial resistance in children with urinary tract infections
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objectives: The aim of this study was to describe antibiotic prescribing patterns and antimicrobial resistance rates in hospitalised children with febrile and afebrile urinary tract infections (UTIs). Methods: Antibiotic prescriptions and antibiograms for neonates, infants and older children with UTI admitted to a general district hospital in Central Greece were evaluated. Data covering a 5-year period were collected retrospectively from the Paediatric Department's Electronic Clinical Archive. Patients were included based on clinical and microbiological criteria. Antimicrobial susceptibility was determined by the Kirby–Bauer disk diffusion method. Results: A total of 230 patients were included in the study. Among 459 prescriptions identified, amikacin (31.2%) was the most common antibiotic prescribed in this population, followed by amoxicillin/clavulanic acid (17.4%) and ampicillin (13.5%). Children received prolonged intravenous (i.v.) treatments for febrile (mean ± S.D., 5.4 ± 1.45 days) and afebrile UTIs (mean ± S.D., 4.4 ± 1.64 days). A total of 236 pathogens were isolated. The main causative organism was Escherichia coli (79.2%) with high reported resistance rates to ampicillin (42.0%), trimethoprim/sulfamethoxazole (26.5%) and amoxicillin/clavulanic acid (12.2%); lower resistance rates were identified for third-generation cephalosporins (1.7%), nitrofurantoin (2.3%), ciprofloxacin (1.4%) and amikacin (0.9%). Klebsiella spp. isolates were highly resistant to cefaclor (27.3%). Conclusion: High prescribing rates for amikacin and penicillins (± β-lactamase inhibitors) and prolonged i.v. treatments were observed. Escherichia coli was highly resistant to ampicillin, whilst third-generation cephalosporins exhibited greater in vitro efficacy. Establishment of antimicrobial stewardship programmes and regular monitoring of antimicrobial resistance could help to minimise inappropriate prescribing for UTIs. © 2019 International Society for Chemotherapy of Infection and Cancer
Συγγραφείς:
Vazouras, K.
Velali, K.
Tassiou, I.
Anastasiou-Katsiardani, A.
Athanasopoulou, K.
Barbouni, A.
Jackson, C.
Folgori, L.
Zaoutis, T.
Basmaci, R.
Hsia, Y.
Περιοδικό:
Journal of Global Antimicrobial Resistance
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
amikacin; amoxicillin; amoxicillin plus clavulanic acid; ampicillin; cefaclor; cefotaxime; cefoxitin; cefprozil; ceftazidime; ceftriaxone; cefuroxime; cephalosporin; ciprofloxacin; cotrimoxazole; imipenem; netilmicin; nitrofurantoin; penicillin G; piperacillin plus tazobactam; succimer; sultamicillin; timentin; amikacin; amoxicillin plus clavulanic acid; ampicillin; antiinfective agent, antibiotic resistance; antibiotic sensitivity; antibiotic therapy; antimicrobial stewardship; Article; blood culture; chemotherapy; child; Citrobacter; cohort analysis; drug efficacy; Enterobacter; Escherichia coli; female; fever; Gram positive cocci; Greece; hospital admission; human; in vitro study; inappropriate prescribing; infant; Klebsiella; major clinical study; male; medical history; newborn; pediatric ward; pediatrics; prescription; priority journal; Proteus; Pseudomonas aeruginosa; public hospital; retrospective study; treatment duration; urinary tract infection; urine culture; adolescent; disk diffusion; drug effect; fever; intravenous drug administration; isolation and purification; microbiology; multidrug resistance; preschool child; urinary tract infection, Administration, Intravenous; Adolescent; Amikacin; Amoxicillin-Potassium Clavulanate Combination; Ampicillin; Anti-Bacterial Agents; Antimicrobial Stewardship; Child; Child, Preschool; Disk Diffusion Antimicrobial Tests; Drug Resistance, Multiple, Bacterial; Escherichia coli; Female; Fever; Greece; Humans; Infant; Infant, Newborn; Klebsiella; Male; Retrospective Studies; Urinary Tract Infections
DOI:
10.1016/j.jgar.2019.06.016
