Περίληψη:
Antiphospholipid syndrome (APS) is a rare disease characterised by venous and/or arterial thrombosis, pregnancy complications and the presence of specific autoantibodies called antiphospholipid antibodies. This review aims to identify existing clinical practice guidelines (CPG) as part of the ERN ReCONNET project, aimed at evaluating existing CPGs or recommendations in rare and complex diseases. Seventeen papers providing important data were identified; however, the literature search highlighted the scarceness of reliable clinical data to develop CPGs. With no formal clinical guidelines in place, diagnosis and treatment of APS is largely based on consensus and expert opinion. Patients' unmet need refers to the understanding of the disease and its clinical picture and implications, the need of education for patients, family members and healthcare providers, as well as to the development of monitoring pathways involving multiple healthcare providers. © 2018 Author(s) (or their employer(s)).
Συγγραφείς:
Limper, M.
Scirè, C.A.
Talarico, R.
Amoura, Z.
Avcin, T.
Basile, M.
Burmester, G.
Carli, L.
Cervera, R.
Costedoat-Chalumeau, N.
Doria, A.
Dörner, T.
Fonseca, J.E.
Galetti, I.
Hachulla, E.
Launay, D.
Lourenco, F.
Macieira, C.
Meroni, P.
Montecucco, C.M.
Moraes-Fontes, M.F.
Mouthon, L.
Nalli, C.
Ramoni, V.
Tektonidou, M.
Van Laar, J.M.
Bombardieri, S.
Schneider, M.
Smith, V.
Vieira, A.
Cutolo, M.
Mosca, M.
Tincani, A.
Λέξεις-κλειδιά:
acetylsalicylic acid; antivitamin K; beta2 glycoprotein 1 antibody; cardiolipin antibody; corticosteroid; eculizumab; gestagen; heparin; hydroxychloroquine; immunoglobulin; low molecular weight heparin; lupus anticoagulant; phospholipid antibody; prednisone; rituximab; rivaroxaban; warfarin, antiphospholipid syndrome; catastrophic antiphospholipid syndrome; clinical practice; drug efficacy; drug safety; fetus death; health care need; health care personnel; human; immunoassay; low birth weight; medical education; patient education; plasma exchange; practice guideline; preeclampsia; primary prevention; Review; spontaneous abortion; systematic review; thrombosis
