Τίτλος:
Soluble ST2 regulation by rhinovirus and 25(OH)-vitamin D3 in the blood of asthmatic children
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Paediatric asthma exacerbations are often caused by rhinovirus (RV). Moreover, 25(OH)-vitamin D3 (VitD3) deficiency during infancy was found associated with asthma. Here, we investigated the innate immune responses to RV and their possible modulation by 25(OH)-VitD3 serum levels in a preschool cohort of children with and without asthma. The innate lymphoid cell type 2 (ILC2)-associated marker, ST2, was found up-regulated in the blood cells of asthmatic children with low serum levels of 25(OH)-VitD3 in the absence of RV in their airways. Furthermore, in blood cells from control and asthmatic children with RV in their airways, soluble (s) ST2 (sST2) protein was found reduced. Asthmatic children with low 25(OH)-VitD3 in serum and with RV in vivo in their airways at the time of the analysis had the lowest sST2 protein levels in the peripheral blood compared to control children without RV and high levels of 25(OH)-VitD3. Amphiregulin (AREG), another ILC2-associated marker, was found induced in the control children with RV in their airways and low serum levels of 25(OH)-VitD3. In conclusion, the anti-inflammatory soluble form of ST2, also known as sST2, in serum correlated directly with interleukin (IL)-33 in the airways of asthmatic children. Furthermore, RV colonization in the airways and low serum levels of 25(OH)-VitD3 were found to be associated with down-regulation of sST2 in serum in paediatric asthma. These data indicate a counter-regulatory role of 25(OH)-VitD3 on RV-induced down-regulation of serum sST2 in paediatric asthma, which is relevant for the therapy of this disease. © 2018 British Society for Immunology
Συγγραφείς:
Haag, P.
Sharma, H.
Rauh, M.
Zimmermann, T.
Vuorinen, T.
Papadopoulos, N.G.
Weiss, S.T.
Finotto, S.
Περιοδικό:
Clinical and Experimental Immunology
Εκδότης:
Wiley-Blackwell Publishing Ltd
Λέξεις-κλειδιά:
amphiregulin; beta interferon; calcifediol; colecalciferol; interleukin 1 receptor like 1 protein; interleukin 1beta; interleukin 2; interleukin 25; interleukin 2ra; interleukin 33; interleukin 7; lactadherin; protein; transmembrane emp24 domaincontaining protein 1; tumor necrosis factor; unclassified drug; colecalciferol; IL1RL1 protein, human; interleukin 1 receptor like 1 protein; interleukin 33, Article; asthma; blood; body fluid; child; clinical article; cohort analysis; controlled study; disease exacerbation; DNA microarray; down regulation; enzyme linked immunosorbent assay; female; forced expiratory volume; human; in vitro study; in vivo study; lymphoid cell; male; mild persistent asthma; moderate persistent asthma; nasopharyngeal fluid; peripheral blood mononuclear cell; preschool child; priority journal; prospective study; protein expression; Rhinovirus; Rhinovirus infection; signal transduction; upregulation; vitamin blood level; vitamin supplementation; asthma; blood; cell culture; common cold; genetics; immunology; innate immunity; metabolism; mononuclear cell; physiology; respiratory system; virology, Asthma; Cells, Cultured; Child; Child, Preschool; Cholecalciferol; Cohort Studies; Common Cold; Disease Progression; Female; Humans; Immunity, Innate; Interleukin-1 Receptor-Like 1 Protein; Interleukin-33; Leukocytes, Mononuclear; Male; Respiratory System; Rhinovirus; Up-Regulation
