Τίτλος:
Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus patients having or not foot ulcer: Possible correlation with other clinical parameters
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Telomerase is the enzyme that maintains telomere length by adding telomeric repeats after each cell division. Numerous metabolic factors such as obesity, insulin resistance or physical inactivity have been associated with shortened telomeres. In the present study, we assessed telomerase activity in diabetic patients having or not foot ulcer. A total of 90 adult patients with type 2 diabetes mellitus (T2DM) were studied. Patients were allocated into two groups according to the absence or presence of active foot ulcers as follows: Νon-ulcer group (N=58) and ulcer group (N=32). Our data revealed that the patients with diabetic ulcers had significantly greater waist circumference and neuropathy disability score, while exhibiting lower telomerase activity, indicating the possible existence of a common clinical profile among ulcer-bearing diabetic patients. Validation of our findings by extending the study in larger patient groups may contribute to the understanding of T2DM pathophysiology and its main clinical implications. © 2018, Spandidos Publications. All rights reserved.
Συγγραφείς:
Baltzis, D.
Meimeti, E.
Grammatikopoulou, M.G.
Roustit, M.
Mavrogonatou, E.
Kletsas, D.
Efraimidou, S.
Manes, C.
Nikolouzakis, T.K.
Tsiaoussis, J.
Tsatsakis, A.M.
Spandidos, D.A.
Trakatelli, C.-M.
Drakoulis, N.
Περιοδικό:
Experimental and Therapeutic Medicine
Εκδότης:
Spandidos Publications
Λέξεις-κλειδιά:
creatinine; hemoglobin A1c; high density lipoprotein cholesterol; low density lipoprotein cholesterol; telomerase; triacylglycerol, adult; aged; Article; body mass; diabetic neuropathy; enzyme activity; female; foot ulcer; human; insulin resistance; leukocyte; major clinical study; male; nociception; non insulin dependent diabetes mellitus; obesity; polymerase chain reaction; waist circumference
DOI:
10.3892/etm.2018.5798
