Τίτλος:
Evaluating genetic susceptibility to Staphylococcus aureus bacteremia in African Americans using admixture mapping
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The incidence of Staphylococcus aureus bacteremia (SAB) is significantly higher in African American (AA) than in European-descended populations. We used admixture mapping (AM) to test the hypothesis that genomic variations with different frequencies in European and African ancestral genomes influence susceptibility to SAB in AAs. A total of 565 adult AAs (390 cases with SAB; 175 age-matched controls) were genotyped for AM analysis. A case-only admixture score and a mixed χ 2 (1df) score (MIX) to jointly evaluate both single-nucleotide polymorphism (SNP) and admixture association (P<5.00e-08) were computed using MIXSCORE. In addition, a permutation scheme was implemented to derive multiplicity adjusted P-values (genome-wide 0.05 significance threshold: P<9.46e-05). After empirical multiplicity adjustment, one region on chromosome 6 (52 SNPs, P=4.56e-05) in the HLA class II region was found to exhibit a genome-wide statistically significant increase in European ancestry. This region encodes genes involved in HLA-mediated immune response and these results provide additional evidence for genetic variation influencing HLA-mediated immunity, modulating susceptibility to SAB. © 2017 Macmillan Publishers Limited. All rights reserved.
Συγγραφείς:
Cyr, D.D.
Allen, A.S.
Du, G.-J.
Ruffin, F.
Adams, C.
Thaden, J.T.
Maskarinec, S.A.
Souli, M.
Guo, S.
Dykxhoorn, D.M.
Scott, W.K.
Fowler, V.G., Jr.
Περιοδικό:
Genes and Immunity
Εκδότης:
Nature Publishing Group
Λέξεις-κλειδιά:
admixture mapping; adult; African American; Article; case control study; chromosome 6; comparative study; controlled study; disease association; female; gene frequency; gene mapping; genetic analysis; genetic susceptibility; genetic variability; genetic variation; genome-wide association study; HLA system; human; immune response; incidence; major clinical study; male; nonhuman; priority journal; prospective study; single nucleotide polymorphism; staphylococcal bacteremia; Staphylococcus aureus; bacteremia; genetic predisposition; genetics; Staphylococcal Infections, African Americans; Bacteremia; Genetic Predisposition to Disease; Humans; Incidence; Polymorphism, Single Nucleotide; Staphylococcal Infections; Staphylococcus aureus
