Τίτλος:
Mixed viral infections of the respiratory tract; an epidemiological study during consecutive winter seasons
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The current study aimed to describe the molecular epidemiology of mixed respiratory viral infections during consecutive winter seasons in a tertiary care hospital. Patients with symptoms of respiratory tract infection were evaluated during the 2009-2011 and 2013-15 winter seasons. A clinical microarray technique was used for viral detection. Clinical and epidemiological data were correlated with mixed viral detection and the need for hospitalization. In 332 out of 604 (54.4%) evaluated patients (17.6% children) a respiratory virus was identified. Mixed viral infections were diagnosed in 68/332 (20.5%) patients with virus detection (66.2% mixed Influenza-RSV infections). Mixed viral infections were more commonly detected in children (OR 3.7; 95%CI 1.9-5.6, P < 0.01) and patients with comorbidities. In logistic regression analyses, mixed viral infections were associated with younger age (mean age 30.4 years vs. 41.8 years, P ≤ 0.001) and increased rates of fever (OR: 2.7; 95%CI 1.04-7.2, P < 0.05) but no adverse outcomes or increased rates of hospitalization. High rates of mixed viral infections were noted during all winter seasons (especially Influenza and RSV) and were more common in younger patients. The clinical significance of mixed respiratory viral infection needs further elucidation. © 2017 Wiley Periodicals, Inc.
Συγγραφείς:
Antalis, E.
Oikonomopoulou, Z.
Kottaridi, C.
Kossyvakis, A.
Spathis, A.
Magkana, M.
Katsouli, A.
Tsagris, V.
Papaevangelou, V.
Mentis, A.
Tsiodras, S.
Περιοδικό:
Journal of Medical Virology
Εκδότης:
John Wiley and Sons Inc
Λέξεις-κλειδιά:
adolescent; adult; age distribution; aged; Article; cardiovascular disease; child; chronic obstructive lung disease; comorbidity; controlled study; disease surveillance; female; human; Human metapneumovirus; Human respiratory syncytial virus; infant; Influenza virus; major clinical study; male; microarray analysis; mixed infection; seasonal variation; tertiary care center; viral respiratory tract infection; virus detection; virus infection; winter; classification; genetics; Greece; hospitalization; isolation and purification; middle aged; mixed infection; molecular diagnosis; molecular epidemiology; newborn; preschool child; prevalence; respiratory tract infection; season; survival analysis; very elderly; virology; virus; virus infection; young adult, Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Coinfection; Female; Greece; Hospitalization; Humans; Infant; Infant, Newborn; Male; Microarray Analysis; Middle Aged; Molecular Diagnostic Techniques; Molecular Epidemiology; Prevalence; Respiratory Tract Infections; Seasons; Survival Analysis; Tertiary Care Centers; Virus Diseases; Viruses; Young Adult
