Τίτλος:
Consensus recommendations for risk stratification in multiple myeloma: Report of the International Myeloma Workshop Consensus Panel 2
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
A panel of members of the 2009 International Myeloma Workshop developed guidelines for risk stratification in multiple myeloma. The purpose of risk stratification is not to decide time of therapy but to prognosticate. There is general consensus that risk stratification is applicable to newly diagnosed patients; however, some genetic abnormalities characteristic of poor outcome at diagnosis may suggest poor outcome if only detected at the time of relapse. Thus, in good-risk patients, it is necessary to evaluate for high-risk features at relapse. Although detection of any cytogenetic abnormality is considered to suggest higher-risk disease, the specific abnormalities considered as poor risk are cytogenetically detected chromosomal 13 or 13q deletion, t(4;14) and del17p, and detection by fluorescence in situ hybridization of t(4;14), t(14;16), and del17p. Detection of 13q deletion by fluorescence in situ hybridization only, in absence of other abnormalities, is not considered a high-risk feature. High serumβ2-microglobulin level and International Staging System stages II and III, incorporating high β 2-microglobulin and low albumin, are considered to predict higher risk disease. There was a consensus that the high-risk features will change in the future, with introduction of other new agents or possibly new combinations. © 2011 by The American Society of Hematology.
Συγγραφείς:
Munshi, N.C.
Anderson, K.C.
Bergsagel, P.L.
Shaughnessy, J.
Palumbo, A.
Durie, B.
Fonseca, R.
Stewart, A.K.
Harousseau, J.-L.
Dimopoulos, M.
Jagannath, S.
Hajek, R.
Sezer, O.
Kyle, R.
Sonneveld, P.
Cavo, M.
Rajkumar, S.V.
San Miguel, J.
Crowley, J.
Avet-Loiseau, H.
Περιοδικό:
Blood advances
Εκδότης:
American Society of Hematology
Λέξεις-κλειδιά:
albumin; beta 2 microglobulin; bortezomib, albumin blood level; cancer chemotherapy; cancer diagnosis; cancer relapse; chromosome deletion 13; conference paper; disease severity; fluorescence in situ hybridization; gene expression; high risk patient; human; multiple myeloma; outcome assessment; priority journal; prognosis
DOI:
10.1182/blood-2010-10-300970
