Τίτλος:
Influence of interleukin 1α (IL-1α), IL-4, and IL-6 polymorphisms on genetic susceptibility to chronic osteomyelitis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The association between cytokine gene polymorphisms and chronic osteomyelitis was investigated in order to determine whether genetic variability in cytokine genes predisposes to osteomyelitis susceptibility. Significant genotypic and allelic associations were observed between interleukin 1α (IL-1α) -889-C/T, IL-4 -1098-G/T and -590-C/T, and IL-6 -174-G/C polymorphisms and osteomyelitis in the Greek population, pointing towards their potential involvement in osteomyelitis pathogenesis. Copyright © 2008, American Society for Microbiology. All Rights Reserved.
Συγγραφείς:
Tsezou, A.
Poultsides, L.
Kostopoulou, F.
Zintzaras, E.
Satra, M.
Kitsiou-Tzeli, S.
Malizos, K.N.
Περιοδικό:
Clinical and Vaccine Immunology (formerly CDLI)
Λέξεις-κλειδιά:
interleukin 1alpha; interleukin 4; interleukin 6; interleukin 1alpha; interleukin 4; interleukin 6, article; chronic osteomyelitis; controlled study; female; genetic polymorphism; genetic susceptibility; genetic variability; Greece; human; major clinical study; male; pathogenesis; priority journal; adult; aged; allele; chronic disease; genetic predisposition; genetics; genotype; middle aged; osteomyelitis; single nucleotide polymorphism; statistical model, Adult; Aged; Aged, 80 and over; Alleles; Chronic Disease; Female; Genetic Predisposition to Disease; Genotype; Greece; Humans; Interleukin-1alpha; Interleukin-4; Interleukin-6; Logistic Models; Male; Middle Aged; Osteomyelitis; Polymorphism, Single Nucleotide
DOI:
10.1128/CVI.00209-08
