Τίτλος:
Polymorphisms of Cx3CR1 and CXCR6 receptors in relation to HAART therapy of HIV type 1 patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The chemokine polymorphisms CXCR6-3E/K, In1.1T/C, H7 haplotype, CX 3CR1-V249I, and CX3CR1-T280M have been shown to affect the course of HIV infection. We studied their influence on immunologic and virologic response to HAART in a group of 143 HIV-1 patients. We performed Kaplan-Meier analysis using the following end-point criteria: (1) time from HAART initiation to undetectable viral load (VL < 50 copies/ml), (2) maximum duration of viral suppression, (3) time from HAART administration until CD4 elevation above 200 cells/μl for patients with baseline CD4 below 200 cells/μl and above 500 cells/μl for patients with baseline CD4 between 200 and 500 cells/μl, respectively, and (4) time from HAART initiation until CD4 reduction below baseline values. Our results revealed an improved immunologic response to HAART in patients with the CX3CR1-249I or CX 3CR1-280M allele. On the contrary, patients with initial VL suppression due to HAART showed a faster virologic failure in the presence of the CXCR6-3K allele. The In1.1T/C polymorphism and H7 haplotype did not reveal any specific effect on HAART response. © Mary Ann Liebert, Inc.
Συγγραφείς:
Passam, A.M.
Sourvinos, G.
Krambovitis, E.
Miyakis, S.
Stavrianeas, N.
Zagoreos, I.
Spandidos, D.A.
Περιοδικό:
AIDS Research and Human Retroviruses
Λέξεις-κλειδιά:
antiretrovirus agent; chemokine receptor CX3CR1; chemokine receptor CXCR6; proteinase inhibitor; RNA directed DNA polymerase inhibitor; unclassified drug, adult; aged; article; CD4 lymphocyte count; controlled study; female; haplotype; highly active antiretroviral therapy; human; Human immunodeficiency virus 1; Human immunodeficiency virus infection; immune response; major clinical study; male; priority journal; protein polymorphism; treatment response; virus load, Adult; Aged; Alleles; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Female; HIV Infections; HIV-1; Humans; Kaplan-Meiers Estimate; Male; Middle Aged; Polymorphism, Genetic; Receptors, Chemokine; Receptors, Virus; Viral Load
DOI:
10.1089/aid.2006.0248
