Τίτλος:
Use of point-of-care molecular tests reduces hospitalization and oseltamivir administration in children presenting with influenza-like illness
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Influenza is associated with increased morbidity, healthcare costs, hospitalization rates, and mortality in children. Rapid immunochromatography assay (ICA), a test with low sensitivity, is often used as point-of-care (POC) test. Recently, the rapid syndromic molecular test FilmArray has become available. This observational study aims to evaluate whether the use of FilmArray would decrease the use of antivirals and hospitalization rates among children presenting to the emergency room (ER) with influenza-like illness (ILI) symptoms. Nasopharyngeal swabs were prospectively collected from children, aged 0–16 years, presenting with ILI at the ER of a tertiary hospital during the peak endemic period. Patients were allocated to be tested by either FilmArray or ICA. The use of antivirals and hospitalization rates were noted. Logistic regression models were used to investigate the impact of testing methods on decision-making. Overall, 80 children were included (mean age: 5 years). Admissions were more likely to occur if an ICA test was performed (OR, 3.16; 95% CI, 1.01–9.82; p =.046). Oseltamivir administration was more likely among children who had undergone the ICA test (OR, 4.67; 95% CI, 1.06–20.43; p =.041). The implementation of rapid molecular test had no impact on complementary diagnostic testing or antibacterial prescription. The use of FilmArray significantly reduced both hospitalization and oseltamivir administration in children. Further knowledge on the use of POC tests is required to improve current management of children presenting with ILI and decrease associated healthcare costs. © 2020 Wiley Periodicals LLC
Συγγραφείς:
Dimopoulou, D.
Vourli, S.
Douros, K.
Pournaras, S.
Papaevangelou, V.
Περιοδικό:
Journal of Medical Virology
Εκδότης:
John Wiley and Sons Inc
Λέξεις-κλειδιά:
oseltamivir; antivirus agent; oseltamivir, adolescent; antiviral therapy; Article; child; child hospitalization; controlled study; decision making; emergency ward; female; flu like syndrome; hospital admission; human; immunoaffinity chromatography; infant; logistic regression analysis; major clinical study; male; nasopharyngeal swab; newborn; observational study; point of care testing; prescription; prospective study; tertiary care center; health care cost; hospital emergency service; hospitalization; immunoassay; influenza; molecular diagnosis; point of care testing; preschool child; procedures; virology; virus infection, Adolescent; Antiviral Agents; Child; Child, Preschool; Emergency Service, Hospital; Female; Health Care Costs; Hospitalization; Humans; Immunoassay; Infant; Infant, Newborn; Influenza, Human; Male; Molecular Diagnostic Techniques; Oseltamivir; Point-of-Care Testing; Prospective Studies; Virus Diseases