Τίτλος:
Type I interferon detection in autoimmune diseases: challenges and clinical applications
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: Accumulating data highlights that the dysregulation of type I interferon (IFN) pathways plays a central role in the pathogenesis of several systemic and organ-specific autoimmune diseases. Advances in understanding the role of type I IFNs in these disorders can lead to targeted drug development as well as establishing potential disease biomarkers. Areas covered: Here, we summarize current knowledge regarding the role of type I IFNs in the major systemic, as well as organ-specific, autoimmune disorders, including prominent inflammatory CNS disorders like multiple sclerosis. Expert opinion: Type I IFN involvement and its clinical associations in a wide spectrum of autoimmune diseases represents a promising area for research aiming to unveil common pathogenetic pathways in systemic and organ-specific autoimmunity. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Papadopoulos, V.E.
Skarlis, C.
Evangelopoulos, M.-E.
Mavragani, C.P.
Περιοδικό:
Expert Review of Clinical Immunology
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
interferon, autoimmune disease; autoimmunity; human; immunotherapy; metabolism; signal transduction, Autoimmune Diseases; Autoimmunity; Humans; Immunotherapy; Interferon Type I; Signal Transduction
DOI:
10.1080/1744666X.2021.1939686
