Τίτλος:
Current understanding and future perspectives of brain–heart–kidney axis in psoriatic arthritis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Psoriatic arthritis (PsA) patients are at a higher risk of systemic inflammatory sequelae, leading to microalbuminuria, cardiovascular (CVD) and neuropsychiatric (NPD) disease. Our aim is to present the existing literature about the relationship between CVD, kidney and NPD in PsA. The literature evaluation of PsA revealed that chronic T-cell activation and increased levels of circulating immune complexes can cause glomerular injury leading to microalbuminuria, which predicts CVD and all-cause mortality in both diabetic and non-diabetic patients. Furthermore, it is a marker of preclinical brain damage and identifies patients at higher risk of NPD/CVD events. Among the currently used imaging modalities in PsA, magnetic resonance imaging (MRI) maintains a crucial role, because it is ideal for concurrent evaluation of brain/heart involvement and serial follow up assessment. There is increasing evidence regarding the relationship between kidneys, heart and brain in PsA. Although currently there are no official recommendations about a combined brain/heart MRI in PsA, it could be considered in PsA with microalbuminuria, arrhythmia, HF, cognitive dysfunction and/or depression. © 2020, Springer-Verlag GmbH Germany, part of Springer Nature.
Συγγραφείς:
Markousis-Mavrogenis, G.
Nurmohamed, M.T.
Koutsogeorgopoulou, L.
Dimitroulas, T.
Katsifis, G.
Vartela, V.
Mitsikostas, D.
Kolovou, G.
Tektonidou, M.
Voulgari, P.
Sfikakis, P.P.
Kitas, G.D.
Mavrogeni, S.I.
Περιοδικό:
Rheumatology International
Λέξεις-κλειδιά:
fluorodeoxyglucose f 18, all cause mortality; antigen antibody complex; brain damage; brain disease; cardiovascular disease; cardiovascular magnetic resonance; cognitive defect; coronary angiography; depression; echocardiography; heart arrhythmia; heart failure; human; kidney disease; microalbuminuria; nuclear magnetic resonance imaging; priority journal; psoriatic arthritis; Review; T lymphocyte activation; cardiovascular disease; central nervous system disease; complication; diagnostic imaging; female; kidney disease; male; pathology; pathophysiology; positron emission tomography-computed tomography; psoriatic arthritis, Arthritis, Psoriatic; Cardiovascular Diseases; Central Nervous System Diseases; Echocardiography; Female; Humans; Kidney Diseases; Magnetic Resonance Imaging; Male; Positron Emission Tomography Computed Tomography
DOI:
10.1007/s00296-020-04633-1
