Τίτλος:
B-cell oligoclonal expansions in renal tissue of patients with immune-mediated glomerular disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
B-cell clonal expansion has been sporadically described in the blood and/or renal tissue of patients with glomerulonephritides, albeit with unclear pathogenetic role. Herein, using spectratyping analysis, we observed oligoclonal intrarenal B-cell populations in 59% of glomerulonephritis patients with podocyte injury (6/7 with focal segmental glomerulosclerosis, 1/3 minimal change disease, 1/3 idiopathic membranous nephropathy, 3/4 IgA nephropathy, 2/5 membranous lupus nephritis), 20% of glomerulonephritis patients without podocyte involvement (4/13 with mesangial or proliferative lupus nephritis, 0/3 idiopathic membranoproliferative glomerulonephritis, 0/4 pauci-immune vasculitis) and 17% of control patients with renal cancer. In multivariate analysis, oligoclonal B-cells were associated with podocyte injury and the grade of glomerulosclerosis (both p = .009). B-cell oligoclonal expansions were not found in the paired peripheral blood samples. We postulate that B-cell expansion in the kidney results from local stimuli, including antigens expressed on podocytes. Further studies to unravel the role of oligoclonal B-cells in (auto)immune-mediated kidney disease are warranted. © 2020 Elsevier Inc.
Συγγραφείς:
Kolovou, K.
Laskari, K.
Roumelioti, M.
Tektonidou, M.G.
Panayiotidis, P.
Boletis, J.N.
Marinaki, S.
Sfikakis, P.P.
Περιοδικό:
Clinical Immunology Newsletter
Εκδότης:
Academic Press Inc.
Λέξεις-κλειδιά:
creatinine; cyclophosphamide; mycophenolate mofetil; rituximab; immunoglobulin heavy chain, adolescent; adult; aged; Article; B lymphocyte; blood sampling; chronic kidney failure; controlled study; creatinine blood level; disease duration; female; focal glomerulosclerosis; glomerulonephritis; glomerulopathy; glomerulosclerosis; human; humoral immune deficiency; idiopathic disease; immunoglobulin A nephropathy; kidney biopsy; kidney tissue; lupus erythematosus nephritis; major clinical study; male; membranoproliferative glomerulonephritis; membranous glomerulonephritis; multivariate analysis; podocyte; priority journal; systemic lupus erythematosus; tissue expansion; urine sampling; B lymphocyte; focal glomerulosclerosis; hematuria; immunoglobulin A nephropathy; immunology; kidney tumor; lupus erythematosus nephritis; membranous glomerulonephritis; middle aged; pathology; proteinuria; very elderly, Aged; Aged, 80 and over; B-Lymphocytes; Female; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Hematuria; Humans; Immunoglobulin Heavy Chains; Kidney Neoplasms; Lupus Nephritis; Male; Middle Aged; Podocytes; Proteinuria
DOI:
10.1016/j.clim.2020.108488
