Τίτλος:
Effects of an Active Surveillance Program and Enhanced Infection Control Measures on Carbapenem-Resistant Gram-Negative Bacterial Carriage and Infections in Pediatric Intensive Care
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We evaluated the effects of enhanced infection control measures (ICMs) on carriage and infections of carbapenem-resistant Gram-negative bacteria (CRGNB) in a pediatric intensive care unit. We conducted a quasi-experimental study, including patients with infections of CRGNB retrospectively for 13 months and those participating in an active surveillance program prospectively for 22 months. Active surveillance (weekly rectal swabs) was implemented during a 63-week subperiod with standard ICMs and a subsequent 27-week subperiod with enhanced ICMs (intensified ICMs supplemented with audits and feedback). Prevalence, colonization pressure, incidence, and infections of CRGNB and compliance with ICMs and enhanced ICMs were recorded. Evaluation of results was performed using time series (TS) and interrupted TS. Compliance with hand hygiene improved during the second subperiod of active surveillance compared with the first; prevalence, colonization pressure, and incidence of CRGNB decreased significantly. The linear trend of centered moving average for carbapenem-resistant Klebsiella pneumoniae (CRKP) decreased from 1.2 to 0.1 infections/1,000 bed-days (IBD) (p = 0.046), while it remained unchanged for carbapenem-resistant Acinetobacter baumannii (CRAB) and increased for carbapenem-resistant Pseudomonas aeruginosa (CRPA) from 0.0 to 2.1 IBD (p < 0.001). Enhanced ICMs can reduce CRKP infections in endemic units, in contrast to CRPA and CRAB infections, which are more difficult to eradicate. © Copyright 2019, Mary Ann Liebert, Inc.
Συγγραφείς:
Karampatakis, T.
Tsergouli, K.
Iosifidis, E.
Antachopoulos, C.
Volakli, E.
Karyoti, A.
Sdougka, M.
Tsakris, A.
Roilides, E.
Περιοδικό:
Microbial Drug Resistance: Mechanism, Epidemiology, and Disease
Εκδότης:
Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA
Λέξεις-κλειδιά:
carbapenem; antiinfective agent; carbapenem derivative, Acinetobacter infection; antibiotic therapy; antimicrobial stewardship; Article; bacterial colonization; carbapenem resistance; carbapenem resistant Acinetobacter baumannii; carbapenem resistant Klebsiella pneumoniae; carbapenem resistant Pseudomonas aeruginosa; child; cleaning; disease carrier; disease surveillance; Enterobacteriaceae infection; female; Gram negative infection; hand washing; human; infection control; infectious disease specialist; intensive care; intestine examination; Klebsiella pneumoniae infection; major clinical study; male; pediatric intensive care unit; priority journal; Pseudomonas infection; quasi experimental study; rectal swab; rectum; retrospective study; staff training; time series analysis; adolescent; antibiotic resistance; drug effect; Gram negative bacterium; Gram negative infection; heterozygote; infant; isolation and purification; microbiology; preschool child; prevalence; prospective study; watchful waiting, Adolescent; Anti-Bacterial Agents; Carbapenems; Carrier State; Child; Child, Preschool; Drug Resistance, Bacterial; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Hand Hygiene; Humans; Infant; Intensive Care Units, Pediatric; Interrupted Time Series Analysis; Male; Prevalence; Prospective Studies; Retrospective Studies; Watchful Waiting
DOI:
10.1089/mdr.2019.0061
