Τίτλος:
Bullous Pemphigoid-like Skin Lesions and Overt Eosinophilia in a Patient with Melanoma Treated with Nivolumab: Case Report and Review of the Literature
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The widespread use of immune checkpoint inhibitors has shed light to several unusual immune-related adverse effects of the drugs. Severe cutaneous adverse reactions are generally rare with anti-PD1 agents. We present in this paper the case of a 48-year-old patient with melanoma who developed bullous pemphigoid-like skin lesions along with fever, arthralgia and overt eosinophilia following adjuvant treatment with nivolumab. The condition was successfully treated with corticosteroids and a rechallenge with another anti-PD1 agent did not lead to recurrence of the skin lesions. We also reviewed the literature on the epidemiologic, clinical, and histopathologic characteristics of bullous pemphigoid as well as on the treatment and prognosis of this dermatologic condition in patients with melanoma or other malignancies under treatment with immune checkpoint inhibitors. © Copyright 2018 Wolters Kluwer Health, Inc. All rights reserved.
Συγγραφείς:
Anastasopoulou, A.
Papaxoinis, G.
Diamantopoulos, P.
Christofidou, E.
Benopoulou, O.
Stratigos, A.
Gogas, H.
Περιοδικό:
Journal of Immunotherapy
Εκδότης:
Lippincott Williams and Wilkins
Λέξεις-κλειδιά:
carboplatin; dacarbazine; immunoglobulin E; ipilimumab; nivolumab; pembrolizumab; prednisolone; immunoglobulin E; immunological antineoplastic agent; nivolumab; prednisolone, adenoma; adjuvant chemotherapy; adult; arthralgia; Article; blister; bullous pemphigoid; cancer combination chemotherapy; cancer immunotherapy; cancer radiotherapy; cancer staging; cancer surgery; case report; clinical article; clinical examination; corticosteroid therapy; drug dose reduction; drug withdrawal; eosinophil count; eosinophilia; erythema; erythrocyte sedimentation rate; exudate; fever; histopathology; human; hyperlipidemia; immunoglobulin blood level; in-transit metastasis; inguinal lymph node; liver metastasis; lymph node dissection; lymph node metastasis; maintenance therapy; male; medical history; melanoma; middle aged; multiple cycle treatment; overt eosinophilia; overt eosinophilia; parotid gland tumor; patient compliance; peritoneum metastasis; polymorphous parotid adenoma; primary tumor; priority journal; sentinel lymph node; skin defect; skin ulcer; smoking; stomach biopsy; tomotherapy; upper limb; wide excision; blood; bullous pemphigoid; complication; eosinophilia; immunology; lymph node; melanoma; metabolism; pathology, Antineoplastic Agents, Immunological; Eosinophilia; Humans; Immunoglobulin E; Lymph Nodes; Male; Melanoma; Middle Aged; Neoplasm Staging; Nivolumab; Pemphigoid, Bullous; Prednisolone
DOI:
10.1097/CJI.0000000000000210
