Τίτλος:
Can we withdraw immunosuppressants in patients with lupus nephritis in remission? An expert debate
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Lupus nephritis (LN) treatment requires an initial intensive period of therapy followed by a long-term maintenance treatment in order to stabilize disease control and eventually reach renal remission. In this section, Authors discuss the feasibility of safely lowering and even suspending maintenance therapy in LN patients having entered remission, highlighting hurdles in predicting the depth and durability of disease quiescence together with the need for minimizing potentially toxic therapies. Even though no firm conclusions can still be drawn, the treating physician has to find the wise balance between disease control and treatment-related drawbacks by following patients closely and recognizing as early as possible the ones who are likely to reach a deep and durable renal remission; there is consensus that is these are the only patients in whom a potential safe complete withdrawal can be foreseen so far. © 2017
Συγγραφείς:
Moroni, G.
Gatto, M.
Raffiotta, F.
Binda, V.
Frangou, E.
Lightstone, L.
Boumpas, D.T.
Περιοδικό:
AUTOIMMUNITY REVIEWS
Λέξεις-κλειδιά:
glucocorticoid; immunosuppressive agent; immunosuppressive agent, clinical outcome; corticosteroid therapy; drug safety; drug withdrawal; human; immunosuppressive treatment; long term care; lupus erythematosus nephritis; maintenance therapy; remission; Review; short course therapy; systemic lupus erythematosus; lupus erythematosus nephritis; pathology; remission, Humans; Immunosuppressive Agents; Lupus Nephritis; Remission Induction
DOI:
10.1016/j.autrev.2017.11.003
