Τίτλος:
Longterm beneficial effect of canakinumab in colchicine-resistant familial mediterranean fever
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective. To assess the efficacy and safety of the interleukin-1β (IL-1β) inhibitor canakinumab in all adolescent and adult patients with familial Mediterranean fever (FMF) identified from the Greek National Registry for off-label drug use between 2010 and 2015. Methods. In this retrospective longitudinal outcome study, clinical and laboratory data were collected from 14 patients (7 men) aged median 38.5 years (range 13-70), with median disease duration of 14 years, and active FMF despite colchicine (n = 9) or both colchicine and anakinra (n = 5). Results.All patients continued to receive canakinumab at last visit (median of 18 mos, range 13-53), which was initially given as monotherapy (n = 8) or in combination with colchicine and/or corticosteroids, every 4 (n = 7), 6 (n = 2), or 8 weeks (n = 5). Eleven patients (79%), including 6 receiving monotherapy, achieved complete clinical remission within 2 months (median), while normalization of all laboratory variables denoting inflammation occurred in 92% at 3 months (median). The remaining 3 patients achieved partial responses. Responses were sustained in all but 4 patients, who relapsed. Reducing the canakinumab administration interval from 8 or 6 weeks to 4 weeks led to suppression of disease activity in the relapsing patients. On the other hand, drug administration interval could be safely increased in 2 patients in remission. Corticosteroid doses were significantly reduced during followup. Canakinumab was well tolerated; 1 patient experienced a urinary tract infection and another one a viral gastroenteritis. Conclusion. Treatment with canakinumab in an individualized dosing scheme results in rapid and sustained remission in colchicine-resistant FMF. © 2016 Journal of Rheumatology.
Συγγραφείς:
Laskari, K.
Boura, P.
Dalekos, G.N.
Garyfallos, A.
Karokis, D.
Pikazis, D.
Settas, L.
Skarantavos, G.
Tsitsami, E.
Sfikakis, P.P.
Περιοδικό:
Indian Journal of Rheumatology
Εκδότης:
Journal of Rheumatology
Λέξεις-κλειδιά:
anakinra; azathioprine; canakinumab; colchicine; corticosteroid derivative; infliximab; methotrexate; methylprednisolone; antiinflammatory agent; canakinumab; colchicine; interleukin 1 receptor blocking agent; monoclonal antibody, adolescent; adult; age distribution; aged; Article; clinical article; clinical examination; controlled study; diarrhea; disease activity; disease duration; disease registry; drug efficacy; drug safety; drug tolerability; drug withdrawal; familial Mediterranean fever; female; follow up; Greece; human; laboratory test; leukopenia; longitudinal study; male; monotherapy; myalgia; off label drug use; priority journal; recurrent disease; remission; retrospective study; sex difference; treatment response; urinary tract infection; viral gastroenteritis; familial Mediterranean fever; middle aged; retreatment; treatment failure; treatment outcome; young adult, Adolescent; Adult; Aged; Anti-Inflammatory Agents; Antibodies, Monoclonal; Colchicine; Familial Mediterranean Fever; Female; Humans; Interleukin 1 Receptor Antagonist Protein; Male; Middle Aged; Off-Label Use; Remission Induction; Retreatment; Retrospective Studies; Treatment Failure; Treatment Outcome; Young Adult
DOI:
10.3899/jrheum.160518
