Τίτλος:
Increased soluble CD72 in systemic lupus erythematosus is in association with disease activity and lupus nephritis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Introduction: B cell receptor (BCR) -mediated signals are enhanced when CD72 expression is deficient on B cells in autoimmune diseases. The significance of soluble CD72 (sCD72) has not been elucidated. Methods: Soluble CD72 was analyzed in the serum of 159 SLE patients, 40 rheumatoid arthritis (RA) patients, and 100 healthy individuals. Correlations between sCD72 and SLE disease activity (SLEDAI) were assessed. Results: Soluble CD72 was found increased in SLE patients, when compared to both RA patients and healthy individuals (20.2 ± 1.2 ng/ml; 10.6 ± 4.6 ng/ml and 7.2 ± 3.3 ng/ml; p < 0.001). Soluble CD72 level was significantly higher in SLE patients with renal involvement than in patients without (31.8 ± 2.3 ng/ml vs 13.9 ± 0.9 ng/ml; p < 0.001) and also with the presence of auto-antibodies. Conclusion: Soluble CD72 is significantly increased in SLE patients mainly in those with renal involvement. Increased sCD72 may become a potential biomarker for renal involvement in SLE. © 2015 .
Συγγραφείς:
Vadasz, Z.
Goldeberg, Y.
Halasz, K.
Rosner, I.
Valesini, G.
Conti, F.
Perricone, C.
Sthoeger, Z.
Bezalel, S.R.
Tzioufas, A.G.
Levin, N.A.
Shoenfeld, Y.
Toubi, E.
Περιοδικό:
Clinical Immunology Newsletter
Εκδότης:
Academic Press Inc.
Λέξεις-κλειδιά:
autoantibody; biological marker; CD72 antigen; lymphocyte antigen; soluble CD72 antigen; unclassified drug; antinuclear antibody; B lymphocyte antigen; biological marker; CD100 antigen; CD72 protein, human; leukocyte antigen; semaphorin, adolescent; adult; Article; clinical assessment; controlled study; correlation analysis; disease activity; disease association; female; human; human tissue; kidney injury; lupus erythematosus nephritis; major clinical study; male; priority journal; receiver operating characteristic; rheumatoid arthritis; sensitivity and specificity; serum; SLEDAI; statistical analysis; systemic lupus erythematosus; B lymphocyte; blood; immunology; middle aged; severity of illness index; systemic lupus erythematosus; young adult, Adolescent; Adult; Antibodies, Antinuclear; Antigens, CD; Antigens, Differentiation, B-Lymphocyte; Arthritis, Rheumatoid; B-Lymphocytes; Biomarkers; Female; Humans; Lupus Erythematosus, Systemic; Male; Middle Aged; Semaphorins; Severity of Illness Index; Young Adult
DOI:
10.1016/j.clim.2016.02.004
