Τίτλος:
Sputum and BAL Clara cell secretory protein and surfactant protein D levels in asthma
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Abstract Clara cell secretory protein (CC16) is associated with Th2 modulation. Surfactant protein D (SPD) plays an important role in surfactant homeostasis and eosinophil chemotaxis. We measured CC16 and SPD in sputum supernatants of 84 asthmatic patients and 12 healthy controls. In 22 asthmatics, we additionally measured CC16 and SPD levels in BAL and assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, and epithelial detachment (ED) in bronchial biopsies. Induced sputum CC16 and SPD were significantly higher in patients with severe asthma (SRA) compared to mild-moderate and healthy controls. BAL CC16 and SPD levels were also higher in SRA compared to mild-moderate asthma. CC16 BAL levels correlated with ED, while SPD BAL levels correlated with SMA and RBM. Severity represented a significant covariate for these associations. CC16 and SPD levels are upregulated in SRA and correlate with remodeling indices, suggesting a possible role of these biomarkers in the remodeling process. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
Συγγραφείς:
Emmanouil, P.
Loukides, S.
Kostikas, K.
Papatheodorou, G.
Papaporfyriou, A.
Hillas, G.
Vamvakaris, I.
Triggidou, R.
Katafigiotis, P.
Kokkini, A.
Papiris, S.
Koulouris, N.
Bakakos, P.
Περιοδικό:
Allergy: European Journal of Allergy and Clinical Immunology
Λέξεις-κλειδιά:
biological marker; Clara cell protein; surfactant protein D; SCGB1A1 protein, human; surfactant protein D; uteroglobin, Article; asthma; basement membrane; bronchus biopsy; controlled study; disease severity; epithelial detachment; human; human tissue; lung lavage; major clinical study; priority journal; respiratory tract parameters; reticular basement membrane; smooth muscle; smooth muscle area; sputum analysis; asthma; biopsy; bronchoalveolar lavage fluid; bronchus; case control study; immunology; pathology; respiratory tract mucosa; severity of illness index; sputum, Asthma; Basement Membrane; Biopsy; Bronchi; Bronchoalveolar Lavage Fluid; Case-Control Studies; Humans; Muscle, Smooth; Pulmonary Surfactant-Associated Protein D; Respiratory Mucosa; Severity of Illness Index; Sputum; Uteroglobin
