Τίτλος:
A prospective study on bacterial and atypical etiology of acute exacerbation in chronic obstructive pulmonary disease
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Aim: The bacterial and atypical etiology of acute exacerbations of chronic obstructive pulmonary disease was investigated and the diagnostic techniques used were compared among 92 hospitalized patients. Materials & methods: Sputum specimens were investigated using culture and PCR, serological status evaluation was performed and the inflammatory profile was associated with the microbiological results. Results & conclusion: The majority of the patients (65.2%) had very severe airway obstruction. The most common bacteria were Haemophilus influenzae and Pseudomonas aeruginosa (23.9 and 14.1%, respectively). Acinetobacter baumannii-and P. aeruginosa-positive cultures were associated with prolonged hospitalization and severe airway obstruction (p = 0.03 and 0.031, respectively). Chlamydia pneumoniae or Mycoplasma pneumoniae infection was diagnosed in four and two patients, respectively. Discrepant results were detected between PCR and serology, especially regarding C. pneumoniae. © 2014 Future Medicine Ltd.
Συγγραφείς:
Nakou, A.
Papaparaskevas, J.
Diamantea, F.
Skarmoutsou, N.
Polychronopoulos, V.
Tsakris, A.
Περιοδικό:
Future Microbiology
Εκδότης:
Future Medicine Ltd
Λέξεις-κλειδιά:
Acinetobacter baumannii; aged; airway obstruction; Article; bacterium detection; chlamydial pneumonia; Chlamydophila pneumoniae; chronic obstructive lung disease; Citrobacter freundii; Corynebacterium striatum; Delftia acidovorans; diagnostic procedure; disease duration; disease exacerbation; Enterobacter cloacae; Escherichia coli; female; Haemophilus influenzae; Haemophilus parainfluenzae; hospital patient; human; Klebsiella pneumoniae; length of stay; lung function; major clinical study; male; Moraxella catarrhalis; Morganella morganii; Mycoplasma pneumonia; Mycoplasma pneumoniae; polymerase chain reaction; prospective study; Pseudomonas aeruginosa; Serratia marcescens; smoking; sputum culture; Streptococcus pneumoniae; bacterium identification; genetics; hospitalization; isolation and purification; microbiology; middle aged; procedures; Pulmonary Disease, Chronic Obstructive; respiratory tract infection; sputum; very elderly, Bacteria (microorganisms); Chlamydophila pneumoniae; Mycoplasma pneumoniae, bacterial DNA, Acinetobacter baumannii; Aged; Aged, 80 and over; Bacterial Typing Techniques; Chlamydophila pneumoniae; DNA, Bacterial; Female; Haemophilus influenzae; Hospitalization; Humans; Male; Middle Aged; Mycoplasma pneumoniae; Polymerase Chain Reaction; Prospective Studies; Pseudomonas aeruginosa; Pulmonary Disease, Chronic Obstructive; Respiratory Tract Infections; Sputum
