Laboratory and clinical characteristics of human west nile virus infections during 2011 outbreak in southern Greece

Επιστημονική δημοσίευση - Άρθρο Περιοδικού uoadl:3003980 9 Αναγνώσεις

Μονάδα:
Ερευνητικό υλικό ΕΚΠΑ
Τίτλος:
Laboratory and clinical characteristics of human west nile virus infections during 2011 outbreak in southern Greece
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
During the summer-autumn of 2011, a human outbreak of West Nile virus (WNV) infection occurred in southern Greece, following the first outbreak during 2010 in northern Greece. An investigation was performed to analyze laboratory diagnosis, geographic distribution, and clinical features of WNV cases in southern Greece. Serum and cerebrospinal fluid (CSF) specimens from all patients seeking laboratory diagnosis for suspected WNV infection were tested for the presence of specific WNV immunoglobulin M (IgM) and IgG antibodies. Detection of WNV RNA in CSF and whole blood samples was accomplished by real-time PCR. During August-October of 2011, 31 confirmed or probable cases of WNV infection were identified. In 25 of them, individuals experienced severe neurological manifestations and were classified as WNV neuroinvasive disease cases. Risk factors such as advanced age, hypertension, and diabetes mellitus were identified in most cases with neurological complications. As many as 25 of the WNV cases occurred in the broader region of Athens; the majority of them (17 cases) were identified in municipalities of Eastern Attica, located almost 40 km from the metropolitan area of Athens and 500 km from Central Macedonia, where the 2010 WNV outbreak occurred. The spread of the virus in a newly affected area of the country suggests that WNV has been established in Greece and disease transmission will be continued in the future. © 2014, Mary Ann Liebert, Inc.
Έτος δημοσίευσης:
2014
Συγγραφείς:
Vrioni, G.
Mavrouli, M.
Kapsimali, V.
Stavropoulou, A.
Detsis, M.
Danis, K.
Tsakris, A.
Περιοδικό:
Vector Borne and Zoonotic Diseases
Εκδότης:
Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA
Τόμος:
14
Αριθμός / τεύχος:
1
Σελίδες:
52-58
Λέξεις-κλειδιά:
immunoglobulin G; immunoglobulin M; immunoglobulin G; immunoglobulin M; virus antibody; virus RNA, adult; age; aged; article; blood analysis; cerebrospinal fluid analysis; clinical article; diabetes mellitus; epidemic; female; Greece; human; hypertension; male; middle aged; neurologic disease; priority journal; real time polymerase chain reaction; risk factor; West Nile fever; blood; demography; enzyme linked immunosorbent assay; epidemic; genetics; geography; immunology; isolation and purification; very elderly; virology; West Nile fever; West Nile flavivirus, Adult; Aged; Aged, 80 and over; Antibodies, Viral; Demography; Disease Outbreaks; Enzyme-Linked Immunosorbent Assay; Female; Geography; Greece; Humans; Immunoglobulin G; Immunoglobulin M; Male; Middle Aged; RNA, Viral; West Nile Fever; West Nile virus
Επίσημο URL (Εκδότης):
DOI:
10.1089/vbz.2013.1369
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