Τίτλος:
Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Studies on cytokine levels in Weil's syndrome are lacking. In this study, TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels were measured in 44 serum samples of patients diagnosed with Leptospira interrogans serovar icterohaemorrhagiae infection. TNF-α levels linked with pulmonary hemorrhagic implications, while elevated sTNFR1 and IL-10 levels linked with fatal cases. IL-6 and IL-8 did not seem to affect the outcome of the disease. Immune response pattern in Weil's syndrome bears resemblance to other patterns described for hemorrhagic fevers. IL-10/TNF-α ratio is proposed as a marker for prognosis. © 2011 Elsevier Ltd.
Συγγραφείς:
Kyriakidis, I.
Samara, P.
Papa, A.
Λέξεις-κλειδιά:
biological marker; interleukin 10; interleukin 6; interleukin 8; tumor necrosis factor alpha; tumor necrosis factor receptor 1, adult; aged; article; bacterial strain; blood sampling; cause of death; controlled study; cytokine response; diagnostic value; disease duration; female; hemorrhagic fever; human; immunopathogenesis; Leptospira interrogans; leptospirosis; lung hemorrhage; male; prediction; priority journal; prognosis; protein blood level; serotype; survival rate; T lymphocyte activation; upregulation, Adult; Aged; Female; Humans; Interleukin-10; Interleukin-6; Interleukin-8; Leptospirosis; Male; Middle Aged; Receptors, Tumor Necrosis Factor, Type I; Tumor Necrosis Factor-alpha, Leptospira interrogans; Leptospira interrogans serovar Icterohaemorrhagiae
DOI:
10.1016/j.cyto.2011.01.014
