Τίτλος:
HBV viremia in newborns of HBsAg(+) predominantly Caucasian HBeAg(-) mothers
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: Hepatitis B virus infection is an important public health problem worldwide and eliminating mother-to-infant transmission is important to decrease the prevalence of chronic HBV-infection. Although, immunoprophylaxis given at birth largely prevents mother-to-infant transmission, perinatal HBV viremia has been reported in HBsAg(-) newborns born mainly to HBeAg(+) women in endemic areas. Objectives: To examine the incidence of perinatal HBV viremia in newborns of HBsAg(+) predominantly HBeAg(-) mothers. Study design: Peripheral blood was obtained at birth from 109 HBsAg(+) mothers and their newborns before the administration of active-passive immunoprophylaxis. Infants were prospectively followed and appropriately vaccinated. Results: Although most (92.7%) of the HBsAg(+) mothers were HBeAg(-), 73.4% had detectable HBV viremia. Neonatal viremia was detected in 3/8 (37.5%) and 24/101 (23.8%) newborns of HBeAg(+) and HBeAg(-) mothers, respectively (p= 0.386). However, HBV-DNA levels were significantly higher in newborns of HBeAg(+) mothers (p= 0.025). No child developed chronic HBV infection, but one child had evidence of subclinical hepatitis. Conclusions: Although the clinical significance of low viremia levels in almost one in four newborns of HBsAg(+) mothers in a low endemicity area is unclear, it may enhance our understanding of HBV mother-to-infant transmission. © 2010 Elsevier B.V.
Συγγραφείς:
Papaevangelou, V.
Paraskevis, D.
Anastassiadou, V.
Stratiki, E.
Machaira, M.
Pitsouli, I.
Haida, C.
Drakakis, P.
Stamouli, K.
Antsaklis, A.
Hatzakis, A.
Περιοδικό:
Journal of Clinical Virology
Λέξεις-κλειδιά:
hepatitis B surface antigen; recombinant hepatitis B vaccine, active immunization; article; blood sampling; Caucasian; female; hepatitis; hepatitis B; human; major clinical study; newborn; newborn infection; passive immunization; priority journal; prospective study; vertical transmission, Child, Preschool; Female; Follow-Up Studies; Hepatitis B; Hepatitis B e Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Humans; Incidence; Infant; Infant, Newborn; Pregnancy; Pregnancy Complications, Infectious; Prospective Studies; Viral Load; Viremia
DOI:
10.1016/j.jcv.2010.11.009
