Τίτλος:
Oral atovaquone for the treatment of severe Pneumocystis jirovecii pneumonia in a patient with glucose-6-phosphate dehydrogenase deficiency
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We present a case of severe Pneumocystis jirovecii pneumonia and coexisting cytomegalovirus infection in a glucose-6-phosphate dehydrogenase (G6PD) enzyme deficient woman with anaplastic astrocytoma on temozolomide and corticosteroid therapy. She was successfully treated with oral atovaquone and ganciclovir. Atovaquone represents a safe alternative in severe Pneumocystis infection when trimethoprimsulfamethoxazole (co-trimoxazole) is contraindicated. © 2009 Informa UK Ltd.
Συγγραφείς:
Douzinas, E.E.
Flevari, K.
Andrianakis, I.
Betrosian, A.P.
Περιοδικό:
Scandinavian Journal of Infectious Diseases
Λέξεις-κλειδιά:
atovaquone; ceftriaxone; dexamethasone; ganciclovir; glucose 6 phosphate dehydrogenase; moxifloxacin; prednisolone; temozolomide; antiinfective agent; atovaquone; glucose 6 phosphate dehydrogenase, adult; article; case report; community acquired pneumonia; cytomegalovirus infection; drug dose reduction; drug indication; drug safety; female; glioblastoma; glucose 6 phosphate dehydrogenase deficiency; human; mixed infection; Pneumocystis jiroveci; Pneumocystis pneumonia; treatment outcome; cytomegalovirus infection; drug effect; genetics; middle aged; oral drug administration; Pneumocystis jiroveci; Pneumocystis pneumonia, Administration, Oral; Anti-Infective Agents; Atovaquone; Cytomegalovirus Infections; Female; Glucosephosphate Dehydrogenase; Humans; Middle Aged; Pneumocystis jirovecii; Pneumonia, Pneumocystis; Treatment Outcome
DOI:
10.3109/00365540903321606
