Τίτλος:
Myocardial performance and aortic elasticity are impaired in patients with ankylosing spondylitis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective To measure aortic stiffness and global left ventricular LV function in patients with ankylosing spondylitis AS and no clinical evidence of heart disease. Methods Fiftyseven consecutive patients with AS 54 males, three females, mean age 41.78±10.02 years without clinical evidence of cardiac involvement and 78 healthy subjects 73 males, five females, mean age 39.92±9.11 years underwent complete echocardiographic study. Aortic stiffness was determined noninvasively by aortic distensibility AoD and the global LV function was evaluated by the myocardial performance index the Tei index. Results AoD in patients with AS 2.21±0.24×10-6 cm2dyn-1 was decreased compared to controls 2.58±0.19 ×10-6 cm2dyn-1, p<0.01, confirming that aortic stiffness is increased in AS. The LV Tei index was significantly increased in the patient group compared to the control group 0.392±0.031 vs. 0.370±0.034, p<0.01. The ejection fraction EF did not differ between the two groups p>0.05. In multivariate linear regression analysis, AoD was significantly associated with the Bath Ankylosing Spondylitis Disease Activity Index BASDAI and LV isovolumic relaxation time IVRT whereas the LV Tei index was associated with BASDAI and the LV mass index. Conclusions Patients with AS and no clinical evidence of cardiac disease have increased stiffness of the aorta and decreased global myocardial performance and both of these abnormal measurements correlate with disease activity. The abnormal Tei index may reflect an early manifestation of cardiac dysfunction in these patients. © 2009 Taylor & Francis on license from Scandinavian Rheumatology Research Foundation. © 2009 Informa UK Ltd All rights reserved.
Συγγραφείς:
Moyssakis, I.
Gialafos, E.
Vassiliou, V.A.
Boki, K.
Votteas, V.
Sfikakis, P.P.
Tzelepis, G.E.
Περιοδικό:
Scandinavian Journal of Rheumatology
Λέξεις-κλειδιά:
corticosteroid; nonsteroid antiinflammatory agent; prednisolone; tumor necrosis factor inhibitor, adult; ankylosing spondylitis; aorta; article; blood vessel compliance; controlled study; demography; echocardiography; female; heart ejection fraction; heart left ventricle function; heart performance; human; major clinical study; male; priority journal; ankylosing spondylitis; aorta; aorta disease; biological model; compliance (physical); early diagnosis; echography; elasticity; heart left ventricle function; middle aged; multivariate analysis; pathophysiology; physiology; statistical model, Adult; Aorta; Aortic Diseases; Compliance; Early Diagnosis; Echocardiography; Elasticity; Female; Humans; Linear Models; Male; Middle Aged; Models, Cardiovascular; Multivariate Analysis; Spondylitis, Ankylosing; Ventricular Function, Left
DOI:
10.1080/03009740802474672
