Περίληψη:
Nonallergic hypersensitivity and allergic reactions are part of the many different types of adverse drug reactions (ADRs). Databases exist for the collection of ADRs. Spontaneous reporting makes up the core data-generating system of pharmacovigilance, but there is a large under-estimation of allergy/hypersensitivity drug reactions. A specific database is therefore required for drug allergy and hypersensitivity using standard operating procedures (SOPs), as the diagnosis of drug allergy/hypersensitivity is difficult and current pharmacovigilance algorithms are insufficient. Although difficult, the diagnosis of drug allergy/hypersensitivity has been standardized by the European Network for Drug Allergy (ENDA) under the aegis of the European Academy of Allergology and Clinical Immunology and SOPs have been published. Based on ENDA and Global Allergy and Asthma European Network (GA2LEN, EU Framework Programme 6) SOPs, a Drug Allergy and Hypersensitivity Database (DAHD®) has been established under FileMaker® Pro 9. It is already available online in many different languages and can be accessed using a personal login. GA2LEN is a European network of 27 partners (16 countries) and 59 collaborating centres (26 countries), which can coordinate and implement the DAHD across Europe. The GA2LEN-ENDA-DAHD platform interacting with a pharmacovigilance network appears to be of great interest for the reporting of allergy/hypersensitivity ADRs in conjunction with other pharmacovigilance instruments. © 2009 The Authors.
Συγγραφείς:
Bousquet, P.-J.
Demoly, P.
Romano, A.
Aberer, W.
Bircher, A.
Blanca, M.
Brockow, K.
Pichler, W.
Torres, M.J.
Terreehorst, I.
Arnoux, B.
Atanaskovic-Markovic, M.
Barbaud, A.
Bijl, A.
Bonadonna, P.
Burney, P.G.
Caimmi, S.
Canonica, G.W.
Cernadas, J.
Dahlen, B.
Daures, J.-P.
Fernandez, J.
Gomes, E.
Gueant, J.-L.
Kowalski, M.L.
Kvedariene, V.
Mertes, P.-M.
Martins, P.
Nizankowska-Mogilnicka, E.
Papadopoulos, N.
Ponvert, C.
Pirmohamed, M.
Ring, J.
Salapatas, M.
Sanz, M.L.
Szczeklik, A.
Van Ganse, E.
De Weck, A.L.
Zuberbier, T.
Merk, H.F.
Sachs, B.
Sidoroff, A.
Λέξεις-κλειδιά:
acetylsalicylic acid; beta lactam antibiotic; immunoglobulin E; nonsteroid antiinflammatory agent, algorithm; allergic reaction; data base; diagnostic approach route; drug hypersensitivity; drug monitoring; drug surveillance program; economic aspect; human; information processing; international cooperation; maculopapular rash; prescription; priority journal; provocation test; reliability; review; skin test; standardization; urticaria; vesicular rash; world health organization, Adverse Drug Reaction Reporting Systems; Anti-Bacterial Agents; beta-Lactams; Databases, Factual; Drug Hypersensitivity; Drug Information Services; Humans; Questionnaires
