Τίτλος:
Evaluation of the immunomodulatory activities of royal jelly components in vitro
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In this work the effect of different components isolated from royal jelly (RJ) was studied using an in vitro rat T-cell proliferation assay. We found that lower concentrations of MEL 174 (final water extract of RJ) and MEL 147 (3-10-dihydroxydecanoic acid) stimulated T-cell proliferation, triggered by concanavalin A (Con-A) and the process was followed by an increase in the production of interleukin-2 (IL-2). Higher concentrations of MEL 174, MEL 247 (dry powder of RJ) and MEL 138 (trans-10-hydroxydec-2-enoic acid) inhibited T-cell proliferation. The inhibition of T-cell proliferation in the presence of MEL 174 was followed by a decrease in IL-2 production, which was partly abrogated by exogenous IL-2, a decrease in nitric oxide (NO) production and increased apoptosis. In conclusion, our results showed the complexity of biological activity of RJ and suggest that its water extract possesses the most potent immunomodulatory activity in vitro. Copyright © Informa Healthcare USA, Inc.
Συγγραφείς:
Gasic, S.
Vucevic, D.
Vasilijic, S.
Antunovic, M.
Chinou, I.
Colic, M.
Περιοδικό:
Immunopharmacology and Immunotoxicology
Λέξεις-κλειδιά:
3,10 dihydroxydecanoic acid; concanavalin A; decanoic acid derivative; interleukin 2; mel 121; mel 138; mel 147; mel 172; mel 174; mel 233; mel 247; n(g) nitroarginine methyl ester; nitric oxide; royal jelly; trans 10 hydroxydec 2 enoic acid; unclassified drug, animal cell; apoptosis; article; cell proliferation; cell stimulation; controlled study; cytokine production; drug effect; dry powder; enzyme synthesis; evaluation; immunomodulation; in vitro study; lymphocyte proliferation; male; nonhuman; priority journal; rat; spleen cell; T lymphocyte, Animals; Apoptosis; Cell Proliferation; Concanavalin A; Fatty Acids; Immunologic Factors; Interleukin-2; Male; Methanol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Solvents; Spleen; T-Lymphocytes, Rattus
DOI:
10.1080/08923970701690977
