Τίτλος:
Concurrent CMV and EBV DNAemia is significantly correlated with a delay in the response to HAART in treatment-naive HIV type 1-positive patients
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The purpose of this study was to assess the qualitative single and multiple herpes virus DNAemia in the peripheral blood leukocytes (PBLs) of HIV-1-positive patients and its impact on the response to highly active antiretroviral therapy (HAART) and immune reconstitution. All (163) HIV-1-positive patients attending "Syngros AIDS Referral Center" from November 2000 to February 2001 were recruited. CMV, HSV-1, HSV-2, EBV, and HHV-8 DNA were detected in PBLs by polymerase chain reaction (PCM). Patients' follow-up comprised regular measurements of CD4+ T cell count and HIV-1 viral load (VL) for an average period of 21 months. Immune reconstitution was defined as an increase in the CD4 T cell count by above 200 cells/μl, while response to HAART was defined as a decrease in HIV-1 VL to undetectable levels. Single and multiple herpetic DNAemia in PBLs was found to be significantly higher in HIV-1-positive patients compared to healthy controls (p < 0.02) for all the viruses detected apart from HSV-2, which was not detected in the PBLs of either population. Concurrent CMV and EBV DNAemia significantly correlates with a delay in the response to HAART (p = 0.033) in treatment-naive patients. Untreated patients with a CD4+ T cell count <200 cells/μl, and with either CMV or EBV DNAemia, presented a delayed increase in the CD4 count after initiation of HAART (p = 0.035 and p = 0.037 respectively), while multiple herpetic DNAemia in the above patients was borderline associated with immune reconstitution (p = 0.068). Conclusively, CMV and EBV DNAemia may be poor prognostic factors for the response to HAART in treatment-naive HIV-1 patients. © Mary Ann Liebart, Inc.
Συγγραφείς:
Panagiotakis, S.H.
Soufla, G.
Baritaki, S.
Sourvinos, G.
Passam, A.
Zagoreos, I.
Stavrianeas, N.
Spandidos, D.A.
Περιοδικό:
AIDS Research and Human Retroviruses
Λέξεις-κλειδιά:
antiretrovirus agent; virus DNA, adult; aged; article; CD4 lymphocyte count; correlation analysis; Cytomegalovirus; cytomegalovirus infection; Epstein Barr virus; female; follow up; Herpes simplex virus 1; Herpes simplex virus 2; highly active antiretroviral therapy; human; Human herpesvirus 8; Human immunodeficiency virus 1 infection; Human immunodeficiency virus infected patient; leukocyte; major clinical study; male; measurement; polymerase chain reaction; priority journal; prognosis; qualitative analysis; unspecified side effect; viremia; virus detection; virus infection; virus load, Adult; Aged; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; CD4 Lymphocyte Count; Cytomegalovirus; Cytomegalovirus Infections; DNA, Viral; Female; Herpesvirus 1, Human; Herpesvirus 2, Human; Herpesvirus 4, Human; Herpesvirus 8, Human; HIV Infections; HIV Seropositivity; HIV-1; Humans; Leukocytes, Mononuclear; Male; Middle Aged; Polymerase Chain Reaction; Viral Load
DOI:
10.1089/aid.2006.0083
