Τίτλος:
IgE sensitization, respiratory allergy symptoms, and heritability independently increase the risk of otitis media with effusion
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background and aims: Epidemiological evidence examining the role of atopy and/or allergy in the pathogenesis of otitis media with effusion (OME) is inconclusive. The aim of this study was to assess any increased risk for OME attributable to allergy-related factors, in a well-characterized population using a case-control design and multivariate analysis. Subjects and methods: Eighty-eight 1-7-year-old children with OME, diagnosed by clinical and tympanometric evaluation and 80 matched controls were enrolled. A standardized questionnaire was completed, in order to assess factors related to OME and allergy-related symptoms and diagnoses using strict clinical definitions. Specific IgE was measured by skin-prick tests and/or CAP-FEIA. Results: The patient and control groups were well matched. Factors conferring increased risk for OME in the univariate analysis included IgE sensitization, dyspnea, wheezing, asthma, paroxysmal sneezing, rhinitis, eczema, 'any allergic disease,' family history of otitis media, and family history of allergy. After multivariate analysis IgE sensitization, wheezing, nasal obstruction, family history of otitis, and child-care attendance remained as independent risk factors for development of OME. Conclusion: IgE sensitization and respiratory allergy symptoms are independent risk factors for the development of OME, suggesting that both immunological and mechanical pathways may contribute to the development of the disease. Otitis heritability provides additional risk, as well as frequent exposure to viral upper respiratory tract infections in children attending daycare. Treatment and/or prevention of OME using anti-allergic medications should be further examined. Copyright © Blackwell Munksgaard 2006.
Συγγραφείς:
Chantzi, F.M.
Kafetzis, D.A.
Bairamis, T.
Avramidou, C.
Paleologou, N.
Grimani, I.
Apostolopoulos, N.
Papadopoulos, N.G.
Περιοδικό:
Allergy: European Journal of Allergy and Clinical Immunology
Λέξεις-κλειδιά:
immunoglobulin E, allergic asthma; allergic rhinitis; analytic method; article; case control study; child; child care; clinical assessment; clinical feature; controlled study; day care; dyspnea; eczema; family history; female; heritability; history; human; immune response; immunology; major clinical study; male; mechanotransduction; multivariate analysis; nose obstruction; otitis media; pathogenesis; priority journal; questionnaire; respiratory tract allergy; risk assessment; risk factor; secretory otitis media; sensitization; skin test; sneezing; symptom; tympanometry; univariate analysis; viral upper respiratory tract infection; wheezing, Age Distribution; Asthma; Case-Control Studies; Child; Child, Preschool; Female; Genetic Predisposition to Disease; Humans; Hypersensitivity, Immediate; Immunization; Incidence; Male; Multivariate Analysis; Otitis Media with Effusion; Probability; Prognosis; Reference Values; Respiratory Hypersensitivity; Risk Assessment; Sex Distribution; Skin Tests; Statistics, Nonparametric
DOI:
10.1111/j.1398-9995.2006.00971.x
