Τίτλος:
The mast cell pathway to inflammation and homeostasis: Pharmacological insights
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Mast cells (MCs) were first described by Paul Ehrlich as well fed granular cells that stain metachromatically. Today MCs are regarded as multifunctional, granulated, tissue-dwelling cells distributed in the perivascular spaces and connective tissues of every major organ of the body. Their long recognized phenotypic diversity might be associated not only with their anatomic distribution and mediator repertoire, but also with their functional characteristics related to the regulation of effector pathways. In addition to their historical involvement in type I hypersensitivity response, MCs have emerged as versatile effector cells with functional diversity and homeostatic functions in non-IgE-mediated inflammatory responses, autoimmunity, bidirectional interactions with the neuroendocrine circuit, the urinary, gastrointestinal, cardiovascular and endocrine systems, in metabolism and malignancy. Thus, MCs appear to receive, integrate and transmit a wide range of signals in their microenviromment, coordinated by the differential release of their pro-inflammatory and anti-inflammatory granular mediators. Understanding the heterogeneity of this complex cellular communication may provide a tool for selective pharmacological intervention directed to specific MC subsets. © 2006 Bentham Science Publishers Ltd.
Συγγραφείς:
Kakavas, S.
Zampeli, E.
Papamichael, K.
Delitheos, B.
Tiligada, E.
Περιοδικό:
Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry
Εκδότης:
Bentham Science Publishers B.V.
Λέξεις-κλειδιά:
17 allylamino 17 demethoxygeldanamycin; acetylsalicylic acid; antalarmin; astressin; chymase inhibitor; cimetidine; corticotropin releasing factor; cyclophosphamide; glucocorticoid; histamine; hydroxyzine; imatinib; immunoglobulin E; immunomodulating agent; ranitidine; sumatriptan; terfenadine; thyroid hormone; thyroxine, allergy; antineoplastic activity; article; asthma; blood brain barrier; blood vessel permeability; cancer; cardiovascular disease; cell differentiation; cell heterogeneity; cell maturation; cell proliferation; cell structure; cellular distribution; chronic inflammation; chronic liver disease; clinical trial; colorectal cancer; Crohn disease; cytokine production; drug mechanism; gastritis; heat shock response; host resistance; human; hypersensitivity reaction; immune response; immune system; immunomodulation; immunoregulation; inflammation; inflammatory disease; leukocyte activation; mast cell; mast cell degranulation; mediator release; metastasis; migraine; multiple sclerosis; nonhuman; pancreas secretion; pathophysiology; signal transduction; stress; tumor growth
DOI:
10.2174/187152306778772793
