Τίτλος:
Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Background: The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. Objective: To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). Patients: Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years. Methods: An open-label, randomized, parallel-group, "real-life" study design was used. Patients received mometasone furoate nasal spray once daily or nedocromil sodium nasal spray 3 times daily starting 2 to 4 weeks before the pollen season and continuing for up to 4 months. Instructions regarding the use of additional medications were given. Diary cards recording symptoms, use of medication, and adverse events were kept by the patients. Results: All 61 patients completed the study. The prophylactic use of mometasone furoate vs nedocromil sodium led to significantly more days without symptoms (75.1% vs 54.5%; P < .001). The mometasone furoate group also had lower nasal symptom scores (mean, 1.4 vs 2.9; median, 0 vs 2; P < .001) and was more satisfied (93.1% vs 43.5%; P < .001). No serious adverse event was recorded, and there was no difference between the treatments in any adverse event. Conclusions: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.
Συγγραφείς:
Pitsios, C.
Papadopoulos, D.
Kompoti, E.
Manoussakis, E.
Garris, V.
Petalas, K.
Tassios, I.
Baibas, N.
Kontou-Fili, K.
Saxoni-Papageorgiou, P.
Papadopoulos, N.G.
Περιοδικό:
Annals of Allergy, Asthma and Immunology
Εκδότης:
American College of Allergy, Asthma and Immunology
Λέξεις-κλειδιά:
mometasone furoate; nedocromil sodium, adolescent; adult; application site burning; article; clinical trial; controlled clinical trial; controlled study; disease severity; drug efficacy; drug safety; epistaxis; female; fever; grass pollen; hay fever; headache; human; insomnia; major clinical study; male; olive; open study; Parietaria; patient satisfaction; pollen allergy; priority journal; prophylaxis; randomized controlled trial; school child; somnolence; taste disorder
DOI:
10.1016/S1081-1206(10)61064-2
