Τίτλος:
Altered immunophenotypic parameters in infertile women. Possible role of herpes viremia
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Problem: Purpose of this study was to reveal any alteration in peripheral blood lymphocytic concentrations of a large cohort of infertile women and to investigate the possible role of herpes viremia in the peripheral immunostimulation. Method of study: The immunophenotypic characteristics and the presence of herpes viruses DNA in the peripheral blood of 168 infertile women were studied. Results: Peripheral CD56+/CD16+ natural killer (NK) cell concentration, CD56+/CD16- NK cell concentration, white blood cell (WBC) concentration and lymphocyte concentration were statistically correlated to herpes viremia. Epstein-Barr virus (EBV) viremia is related with a limited reduction of CD56+/CD16- cell levels in the peripheral blood of infertile women with regard to the rest of herpes viruses. High T-lymphocyte concentration, CD4+ T-cell concentration and CD8+ T-cell concentration was observed in women positive for three different kinds of herpes viruses (triple viremia) in the peripheral blood. Conclusions: Assuming that all women under study remained asymptomatic, these data suggest that subclinical herpesvirus viremia may be an important cause of peripheral immunostimulation in women with a history of infertility. © 2005 Blackwell Munksgaard.
Συγγραφείς:
Thomas, D.
Michou, V.
Moustakarias, T.
Aleporou, V.
Matzavinos, T.
Mitsakos-Barbagiannis, K.
Kalofoutis, A.
Tsilivakos, V.
Περιοδικό:
American Journal of Reproductive Immunology
Λέξεις-κλειδιά:
CD16 antigen; CD4 antigen; CD56 antigen; CD8 antigen, adult; article; cohort analysis; controlled study; correlation analysis; Epstein Barr virus; female; female infertility; herpes; human; immunological parameters; immunophenotyping; immunostimulation; leukocyte count; lymphocyte count; major clinical study; natural killer cell; peripheral lymphocyte; priority journal; statistical analysis; T lymphocyte; T lymphocyte subpopulation; viremia, Adult; Antigens, CD; CD4-CD8 Ratio; Epstein-Barr Virus Infections; Female; Humans; Infertility, Female; Lymphocytes; Viremia
DOI:
10.1111/j.1600-0897.2005.00293.x
