Τίτλος:
Blood eosinophils as predictor of outcomes in patients hospitalized for COPD exacerbations: a prospective observational study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: In the present prospective multicentre observational study, we evaluated the potential role of blood eosinophils on the outcomes of patients hospitalized for COPD exacerbations. Material and methods: Consecutive patients >40 years with a previous COPD diagnosis were recruited. Blood eosinophils were measured on admission prior to the initiation of treatment and were evaluated in three groups (<50, 50–149 and ≥150 cells/μL). Patients received standard care and were followed up for a year. Results: A total of 388 patients were included (83.5% male, mean age 72 years). Patients with higher blood eosinophils had less dyspnoea (Borg scale), lower C-reactive protein (CRP) and higher PaO2/FiO2 (partial pressure for oxygen/fraction of inhaled oxygen), and were discharged earlier (median 11 vs. 9 vs. 5 days for patients with <50, 50–149 and ≥150 cells/μL, respectively). Patients with <50 cells/μL presented higher 30-day and 1-year mortality, whereas there were no differences in moderate/severe COPD exacerbations between the three groups. In a post hoc analysis, treatment with inhaled corticosteroids as per physicians’ decision was associated with better exacerbation prevention during follow-up in patients with ≥150 cells/μL. Conclusions: Higher blood eosinophils were associated with better outcomes in hospitalized COPD patients, further supporting their use as a prognostic biomarker. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Kostikas, K.
Papathanasiou, E.
Papaioannou, A.I.
Bartziokas, K.
Papanikolaou, I.C.
Antonakis, E.
Makou, I.
Hillas, G.
Karampitsakos, Τ.
Papaioannou, O.
Dimakou, K.
Apollonatou, V.
Verykokou, G.
Papiris, S.
Bakakos, P.
Loukides, S.
Περιοδικό:
Biomarker Insights
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
antibiotic agent; biological marker; C reactive protein; corticosteroid; C reactive protein; corticosteroid, aged; Article; blood; chronic obstructive lung disease; clinical decision making; clinical evaluation; controlled study; disease exacerbation; dyspnea; eosinophil; female; follow up; fraction of inspired oxygen; Horowitz index; hospital admission; hospital discharge; hospital patient; human; major clinical study; male; mortality; multicenter study; observational study; outcome assessment; post hoc analysis; predictive value; prospective study; blood; chronic obstructive lung disease; clinical trial; disease exacerbation; eosinophil; hospitalization; Kaplan Meier method; length of stay; leukocyte count; metabolism; middle aged; prognosis; prospective study, Adrenal Cortex Hormones; Aged; C-Reactive Protein; Disease Progression; Eosinophils; Female; Hospitalization; Humans; Kaplan-Meier Estimate; Length of Stay; Leukocyte Count; Male; Middle Aged; Outcome Assessment, Health Care; Prognosis; Prospective Studies; Pulmonary Disease, Chronic Obstructive
DOI:
10.1080/1354750X.2021.1903998
