Τίτλος:
Usefulness of F2-isoprostanes in early prognostication after cardiac arrest: a topical review of the literature and meta-analysis of preclinical data
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Prognostication after cardiac arrest (CA) represents a challenging issue, and several biomarkers have been proposed in the attempt to predict outcome. Among these, F2-isoprostanes stand out as potential biomarkers for early prognostication, providing information on the magnitude of global oxidative injury after return of spontaneous circulation (ROSC). We performed a topical review searching PubMed and Scopus databases to identify studies evaluating the modifications of F2-isoprostanes in the early period after CA, and a meta-analysis of studies providing curves of F2-isoprostanes plasma levels seeking to describe the biomarker’s kinetics after CA. Evidence suggests that plasma levels of F2-isoprostanes increase in the early post-resuscitation period and seem well correlated with the burden of ischaemia-reperfusion injury. Our meta-analysis shows a possible increase as early as 5 minutes after ROSC, which persists at 2 hours and is attenuated at 4 hours. Clinical studies are warranted to evaluate the utility of this biomarker for prognostication purposes in CA survivors. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Karlis, G.
Kotanidou, A.
Georgiopoulos, G.
Masi, S.
Magkas, N.
Xanthos, T.
Περιοδικό:
Biomarker Insights
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
essential fatty acid; isoprostane derivative; biological marker; isoprostane derivative, drug blood level; heart arrest; human; lipid peroxidation; meta analysis; oxidative stress; prognosis; reperfusion injury; resuscitation; return of spontaneous circulation; Review; survivor; blood; early diagnosis; genetics; out of hospital cardiac arrest; pathology, Biomarkers; Cardiopulmonary Resuscitation; Early Diagnosis; F2-Isoprostanes; Humans; Out-of-Hospital Cardiac Arrest; Oxidative Stress; Prognosis; Reperfusion Injury
DOI:
10.1080/1354750X.2020.1754465
