Τίτλος:
Soluble urokinase plasminogen activator receptor informs on the progression course after multiple injuries
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Purpose: The purpose of this study is to study the use of soluble urokinase plasminogen activator receptor (suPAR) for the prognosis of multiple organ dysfunction (MOF) after multiple traumas. Methods: Serum suPAR was measured within the first 24 h after multiple injuries in 85 patients. Measurements were repeated after 4 d or at sepsis onset. Results: Odds ratio for trauma-associated MOF was 4.09 (p: 0.026) with admission suPAR greater than 8 ng/ml. More than 40% increases of suPAR were associated with odds ratio 9.33 (p: 0.047) for severe sepsis. Conclusions: suPAR is a useful surrogate biomarker for development of MOF and severe sepsis after multiple traumas. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Συγγραφείς:
Patrani, M.
Tsaganos, T.
Kotzampassi, K.
Paraschos, M.
Katsenos, C.
Giamarellos-Bourboulis, E.J.
Mandragos, K.
Περιοδικό:
Biomarker Insights
Εκδότης:
Taylor and Francis Ltd.
Λέξεις-κλειδιά:
urokinase receptor; biological marker; isoprotein; urokinase receptor, adult; Article; bloodstream infection; female; Greece; hospital admission; human; intensive care unit; major clinical study; male; multiple organ failure; multiple trauma; predictive value; protein blood level; blood; complication; disease course; multiple organ failure; multiple trauma; odds ratio; sepsis, Biomarkers; Disease Progression; Humans; Multiple Organ Failure; Multiple Trauma; Odds Ratio; Protein Isoforms; Receptors, Urokinase Plasminogen Activator; Sepsis
DOI:
10.3109/1354750X.2016.1171911
