Τίτλος:
A novel noninvasive index for nonalcoholic steatohepatitis: A pilot study
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Objective: The potential development of a noninvasive marker predicting nonalcoholic steatohepatitis (NASH). Methods: Thirty patients with biopsy-proven nonalcoholic fatty liver disease were evaluated by numerous anthropometric, clinical and biochemical parameters. Results: Serum glutamic oxaloacetic transaminase (SGOT; p=0.027), log (erythrocyte sedimentation rate) (ESR; p=0.034) and homocysteine (p=0.041) were associated with NASH independently from gender, age and body mass index. When combined, the regression model provided R2=0.563 (p=0.001) and area under the ROC curve=0.873±0.066 (p<0.001). Conclusion: This noninvasive marker, named HSENSI (acronym of homocysteine, SGOT, ESR, Nonalcoholic Steatohepatitis Index), consists of three low cost, easily measurable parameters and may accurately predict NASH. © 2013 Informa UK Ltd.
Συγγραφείς:
Polyzos, S.A.
Kountouras, J.
Slavakis, A.
Zafeiriadou, E.
Patsiaoura, K.
Katsiki, E.
Zavos, C.
Papatheodorou, A.
Terpos, E.
Περιοδικό:
Biomarker Insights
Λέξεις-κλειδιά:
aspartate aminotransferase; homocysteine, adult; anthropometric parameters; article; aspartate aminotransferase blood level; biochemistry; body mass; clinical article; controlled study; diagnostic test accuracy study; diagnostic value; erythrocyte sedimentation rate; female; human; liver biopsy; liver function test; male; nonalcoholic fatty liver; Nonalcoholic Fatty Liver Disease Activity Score; pilot study; predictive value; receiver operating characteristic; sensitivity and specificity, Aspartate Aminotransferases; Biological Markers; Blood Sedimentation; Cross-Sectional Studies; Fatty Liver; Female; Greece; Homocysteine; Humans; Male; Middle Aged; Pilot Projects; ROC Curve
DOI:
10.3109/1354750X.2013.838305
