Τίτλος:
Effects of electronic cigarette on platelet and vascular function after four months of use
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
We examined the effects of electronic cigarette on platelet and vascular function after 4 months of use compared to tobacco smoking. Forty smokers without cardiovascular disease were randomized to smoke either conventional cigarettes or an electronic cigarette (nicotine concentration of 12 mg/ml). At baseline and after four months, we measured a) platelet function by Platelet Function Analyzer PFA-100 and Light Transmission Aggregometry, b) pulse wave velocity, c) plasma malondialdehyde levels as oxidative stress index and d) the exhaled CO level. After 4 months, continuation of conventional cigarette smoking further impaired platelet function compared to vaping as assessed by PFA (mean increase 27.1 vs 11.6 s, p for interaction = 0.048) and by LTA (decline 24.1 vs 9.4%, p for interaction = 0.045). Conversely, compared to smoking, vaping resulted in greater reduction of exhaled CO (6.9 ppm vs 2.6, p for interaction < 0.001), improvement of PWV (decrease of 0.8 m/s vs increase of 0.8 m/s, p for interaction = 0.020) and reduction of MDA (reduction 0.13 vs increase 0.19 nmol/L, p for interaction = 0.035). Switching to electronic cigarette for 4 months has a neutral effect on platelet function while it reduces arterial stiffness and oxidative stress compared to tobacco smoking. © 2020 Elsevier Ltd
Συγγραφείς:
Ikonomidis, I.
Katogiannis, K.
Kostelli, G.
Kourea, K.
Kyriakou, E.
Kypraiou, A.
Tsoumani, M.
Andreadou, I.
Lambadiari, V.
Plotas, P.
Thymis, I.
Tsantes, A.E.
Περιοδικό:
Food and Chemical Toxicology
Εκδότης:
Elsevier Ireland Ltd
Λέξεις-κλειδιά:
carbon monoxide; malonaldehyde; nicotine; nicotine, adult; arterial stiffness; artery compliance; Article; blood level; blood vessel function; breath analysis; carotid artery; cigarette smoking; controlled study; current smoker; female; femoral artery; human; human cell; male; oxidative stress; platelet aggregation assay; pulse wave; shear stress; thrombocyte function; vaping; drug effect; electronic cigarette; physiology; thrombocyte; vascular endothelium, Blood Platelets; Electronic Nicotine Delivery Systems; Endothelium, Vascular; Humans; Nicotine
DOI:
10.1016/j.fct.2020.111389
