Τίτλος:
Composition, antimicrobial, antiradical and spasmolytic activity of Ferula heuffelii Griseb. ex Heuffel (Apiaceae) essential oil
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
The essential oil from underground parts of Ferula heuffelii from N.E. Serbia, was analysed using GC and GC-MS. The main compounds of the essential oil were elemicin (35.4%) and myristicin (20.6%). The essential oil exhibited the best antimicrobial activity against two strains of Candida albicans (MIC = 7.0 and 13.7 μg/ml), as well as against Micrococcus luteus (MIC = 13.7 μg/ml), Staphylococcus epidermidis (MIC = 17.6 μg/ml), Bacillus subtilis (MIC = 21.1 μg/ml) and Micrococcus flavus (MIC = 28.2 μg/ml). In the DPPH radical scavenging assay, essential oil showed substantial activity with SC50 = 22.43 μl/ml. The essential oil was also tested for antispasmodic activity. It inhibited spontaneous contraction of isolated rat ileum dose-dependently, and at the concentration of 86.64 μg/ml exhibited 50% of the maximum effect of atropine. After incubation with 75.00 μg/ml of essential oil, acetylcholine did not induce contractions of ileum, and at 250.00 μg/ml, the essential oil almost completely abolished the spasmodic effect of potassium chloride (80 mM). © 2011 Elsevier Ltd. All rights reserved.
Συγγραφείς:
Pavlović, I.
Petrović, S.
Radenković, M.
Milenković, M.
Couladis, M.
Branković, S.
Drobac, M.P.
Niketić, M.
Περιοδικό:
Food Chemistry
Λέξεις-κλειδιά:
Anti-microbial activity; Antiradical activities; Antispasmodic activity; Essential oil composition; Ferula heuffelii, Bacteriology; Chlorine compounds; Microorganisms; Potassium, Essential oils, 1,1 diphenyl 2 picrylhydrazyl; acetylcholine; amikacin; amphotericin; ampicillin; ascorbic acid; atropine; ciprofloxacin; elemicin; essential oil; myristicin; nystatin; potassium chloride; radical; streptomycin, animal experiment; antifungal activity; antimicrobial activity; antioxidant activity; Apiales; article; Bacillus subtilis; Candida albicans; chemical composition; controlled study; drug determination; Ferula heuffelii; fungal strain; gas chromatography; ileum; ileum contraction; incubation time; mass fragmentography; medicinal plant; Micrococcus luteus; minimum inhibitory concentration; nonhuman; rat; scavenging system; Serbia; spasmolysis, Apiaceae; Bacillus subtilis; Candida albicans; Ferula; Micrococcus luteus; Rattus; Staphylococcus epidermidis
DOI:
10.1016/j.foodchem.2011.07.043
