Τίτλος:
Terpenes from the Red Alga Sphaerococcus coronopifolius Inhibit the Settlement of Barnacles
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
In this study, we screened eight terpenes isolated from the organic extract of Sphaerococcus coronopifolius for their antifouling activity in order to find possible new sources of non-toxic or less toxic bioactive antifoulants. The anti-settlement activity (EC 50) and the degree of toxicity (LC 50) of S. coronopifolius metabolites was evaluated using larvae of the cirriped crustacean Amphibalanus (Balanus) amphitrite (cyprids and nauplii) as model organism. For five of eight tested metabolites EC 50 was lower than 5 mg/L. The most promising results were observed for bromosphaerol (3), which expressed an EC 50 value of 0.23 mg/L, in combination with low toxicity levels (LC 50 > 100 mg/L). The therapeutic ratio-an index used to estimate whether settlement inhibition is due to toxicity or other mechanisms-is also calculated and discussed. © 2010 Springer Science+Business Media, LLC.
Συγγραφείς:
Piazza, V.
Roussis, V.
Garaventa, F.
Greco, G.
Smyrniotopoulos, V.
Vagias, C.
Faimali, M.
Περιοδικό:
Marine Biotechnology
Λέξεις-κλειδιά:
Antifoulants; Antifouling; Antifouling activity; Balanus; Barnacle; Low toxicity; Marine natural products; Model organisms; New sources; Organic extracts; Red algae; Settlement inhibition; Sphaerococcus coronopifolius, Lipids; Metabolism; Metabolites; Toxicity, Olefins, plant extract; terpene, animal product; antifouling; antifouling agent; bioactivity; biofouling; biotechnology; crustacean; ecotoxicology; inhibitor; marine environment; metabolite; red alga; terpene; toxicity test, animal; animal behavior; article; chemical structure; chemistry; drug effect; isolation and purification; larva; LD 50; red alga; Thoracica, Animals; Behavior, Animal; Larva; Lethal Dose 50; Molecular Structure; Plant Extracts; Rhodophyta; Terpenes; Thoracica, Amphibalanus; Amphitrite; Balanus; Crustacea; Cyprididae; Rhodophyta; Sphaerococcus coronopifolius; Thoracica
DOI:
10.1007/s10126-010-9337-4