Τίτλος:
Aerophobin-1 from the Marine Sponge Aplysina aerophoba Modulates Osteogenesis in Zebrafish Larvae
Γλώσσες Τεκμηρίου:
Αγγλικά
Περίληψη:
Longer life expectancy has led to an increase in efforts directed to the discovery of new healing agents for disorders related to aging, such as bone diseases. Harboring an incredible variety of bioactive metabolites, marine organisms are standing out as fruitful sources also in this therapeutic field. On the other hand, the in vivo zebrafish model has proven to be an excellent low-cost screening platform for the fast identification of molecules able to regulate bone development. By using zebrafish larvae as a mineralization model, we have thus evaluated the effects of the crude acetonic extract from the marine sponge Aplysina aerophoba and its bromotyrosine components on bone development. Obtained results led to the selection of aerophobin-1 (1) as a promising candidate for applications in regenerative medicine, paving the way for the development of a novel therapeutic option in osteoporosis treatment. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
Συγγραφείς:
Carnovali, M.
Ciavatta, M.L.
Mollo, E.
Roussis, V.
Banfi, G.
Carbone, M.
Mariotti, M.
Λέξεις-κλειδιά:
aerophobin 1; aerophobin 2; aeroplysinin; Aplysina aerophoba extract; fisturalin 3; LL PAA 216; natural product; tyrosine derivative; unclassified drug; uranidine, animal experiment; animal tissue; Aplysina aerophoba; Article; bone development; bone mineralization; concentration response; controlled study; drug determination; drug isolation; drug screening; drug structure; embryo; in vivo study; marine species; metabolite; nonhuman; osteoporosis; regenerative medicine; zebra fish
