Περίληψη:
Background/Aim: Evidence suggests a beneficial effect of prone positioning (PP) in COVID-19. Materials and Methods: Meta-analysis of individual (7 investigators’ groups) and aggregate data (PubMed/EMBASE) regarding the impact of PP on the ratio of arterial partial pressure of oxygen to fraction of inspired oxygen (PO2/FiO2) in patients with COVID-19. Results: Among 121 patients (mean age±SD 59.1±10.7 years, 55% males, 57% intubated) the mean post-versus pre- PP PO2/FiO2 difference was: (i) 50.4±64.3 mmHg, p<0.01, (ii) similar in awake (58.7±72.1 mmHg) versus intubated patients (44.1±57.5 mmHg, p=NS), (iii) inversely correlated with body mass index (r=–0.43, p<0.01). Meta-analysis of 23 studies (n=547, weighted age 58.3±4.1, 73% males, 59% intubated) showed a pooled PO2/FiO2 difference of 61.8 [95% confidence intervals=49.9-73.6] mmHg. Meta-regression analysis revealed no associations with baseline demographics, the time in PP before assessment, and the risk of bias of the studies. Conclusion: PP seems to improve oxygenation of patients with COVID-19. © 2022 International Institute of Anticancer Research. All rights reserved.
Συγγραφείς:
Kollias, A.
Kyriakoulis, K.G.
Rapti, V.
Trontzas, I.P.
Nitsotolis, T.
Syrigos, K.
Poulakou, G.
THE PROPCOR CONSORTIUM-7 INVESTIGATOR SOSAMA ABOU-ARAB, BERNARD ALLAOUCHICHE, ALFREDO J. ASTUA, KALOMOIRA ATHANASIOU, FRANCESCO BARONE-ADESI, DAMIEN BASILLE, CHRISTOPHE BEYLS, EMMANUEL BOSELLI, ATHINA DAPERGOLA, LUCA GRILLENZONI, PRERANA JAIN, ELENI KAKALOU, SMARAGDI KALOMOIRI, STANISLAS LEDOCHOWSKI, WEIHUA LU, ANDREW J. MICHAELS, ELI K. MICHAELS, ALBA RIPOLL-GALLARDO, PRABHANJAN SINGH, TAO WANG, QIANCHENG XU
Λέξεις-κλειδιά:
oxygen, female; human; male; meta analysis; middle aged; multicenter study (topic); prone position; register, COVID-19; Female; Humans; Male; Middle Aged; Multicenter Studies as Topic; Oxygen; Prone Position; Registries; SARS-CoV-2
